{"id":"W1856093924","doi":"10.3109/15563650.2015.1104539","title":"Letter in reply to Riggan et al. Re: External validation of the paracetamol-aminotransferase multiplication product to predict hepatotoxicity from paracetamol overdose","year":2015,"lang":"en","type":"letter","venue":"Clinical Toxicology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Medicine; Acetaminophen; Pharmacology; Drug overdose; Emergency medicine; Poison control","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.006929008,0.0008627669,0.001717497,0.0004048868,0.0002373174,0.00005546731,0.001525088,0.003025984,0.0004892815],"category_scores_gemma":[0.003993917,0.0007624827,0.0005948328,0.0008795413,0.000520769,0.0002602813,0.0005208123,0.009476733,0.0005113287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006612218,"about_ca_system_score_gemma":0.000630367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006043675,"about_ca_topic_score_gemma":0.0003971363,"domain_scores_codex":[0.9837732,0.009285732,0.002905079,0.002141814,0.0008057255,0.001088393],"domain_scores_gemma":[0.9929876,0.003120869,0.001077077,0.001838931,0.0004437098,0.0005317848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001677847,0.001264406,0.03939648,0.0001049904,0.0002523034,0.000141801,0.0007720915,0.0009589711,0.03221411,0.00001901124,0.9161106,0.007087414],"study_design_scores_gemma":[0.002654542,0.0007012486,0.02459111,0.0001835903,0.0002457051,0.00002122345,0.000009525405,0.0004393187,0.08971348,0.0006749064,0.8800443,0.0007211029],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5147051,0.00007337,0.0004174215,0.4747757,0.00479352,0.004270238,0.0006124831,0.0001006106,0.0002516343],"genre_scores_gemma":[0.3177239,0.0001039302,0.0005875358,0.6767449,0.003050181,0.0009512494,0.0002630532,0.00009279266,0.0004825171],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.2019692,"threshold_uncertainty_score":0.9994826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2330379801611834,"score_gpt":0.4708702541764115,"score_spread":0.2378322740152281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}