{"id":"W1856321184","doi":"10.4049/jimmunol.0802442","title":"The Immunostimulatory Activity of Unmethylated and Methylated CpG Oligodeoxynucleotide Is Dependent on Their Ability To Colocalize with TLR9 in Late Endosomes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada); Arthritis Research Centre of Canada; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"TLR9; Colocalization; CpG site; CpG Oligodeoxynucleotide; DNA methylation; Endosome; Biology; DNA; Molecular biology; Methylation; Toll-Like Receptor 9; Cell biology; Gene; Biochemistry; Gene expression; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000375145,0.0003197677,0.0002580022,0.0001711785,0.0001121847,0.0002670517,0.0001868561,0.0003652472,0.001404742],"category_scores_gemma":[0.0003253403,0.0001607206,0.0002590216,0.0000973073,0.0002648661,0.0002294332,0.0002494784,0.0005142324,0.0002479645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187262,"about_ca_system_score_gemma":0.0002095777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001719091,"about_ca_topic_score_gemma":0.000278211,"domain_scores_codex":[0.9997193,0.00007599212,0.00002342239,0.00004708982,0.00007228614,0.00006172263],"domain_scores_gemma":[0.9997882,0.00006908627,0.00004110218,0.00002300561,0.00002854743,0.0000499605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000113553,0.0000174282,0.00007049221,0.00002864716,0.000003797632,0.00001444972,0.000005412875,0.00002702388,0.9986103,0.00007245564,0.000006143285,0.001030362],"study_design_scores_gemma":[0.0000128237,0.0005027094,0.001692139,0.000006580282,0.0000105824,0.000110978,0.000008741025,0.0003408617,0.9966239,0.00004747695,0.0006395897,0.000003678823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894614,0.002873502,0.0055141,0.00007892201,0.00005157291,0.00004627743,0.00008559464,0.00002578177,0.00186299],"genre_scores_gemma":[0.9942222,0.0007062879,0.003695267,0.00008308438,0.00001711643,0.00004285591,0.0001396785,0.000008671208,0.001084844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404742,"threshold_uncertainty_score":0.00469929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006351822160567649,"score_gpt":0.2307857867030808,"score_spread":0.2244339645425132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}