{"id":"W1856321184","doi":"10.4049/jimmunol.0802442","title":"The Immunostimulatory Activity of Unmethylated and Methylated CpG Oligodeoxynucleotide Is Dependent on Their Ability To Colocalize with TLR9 in Late Endosomes","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada); Arthritis Research Centre of Canada; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"TLR9; Colocalization; CpG site; CpG Oligodeoxynucleotide; DNA methylation; Endosome; Biology; DNA; Molecular biology; Methylation; Toll-Like Receptor 9; Cell biology; Gene; Biochemistry; Gene expression; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002705983,0.0002289807,0.0005274665,0.0002308949,0.0002521711,0.00001382975,0.0005274655,0.0002915532,0.0000931204],"category_scores_gemma":[0.0005019585,0.000114901,0.00008901995,0.0002570657,0.0007516094,0.0001283695,0.0001432684,0.001231847,0.00002174887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005590143,"about_ca_system_score_gemma":0.0001534049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002353068,"about_ca_topic_score_gemma":0.0001511773,"domain_scores_codex":[0.9972917,0.001433482,0.0006849301,0.0001544131,0.00007827252,0.0003572417],"domain_scores_gemma":[0.9961267,0.002410488,0.0006367757,0.0005520562,0.0002525469,0.00002145129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0117536,0.000120568,0.00063407,0.00000602871,0.0004699041,0.000004562641,0.002407372,0.0002030951,0.9707823,0.0001961005,0.00003196552,0.01339039],"study_design_scores_gemma":[0.002244289,0.001544672,0.1184212,0.00004810228,0.0000636863,0.0001795973,0.0003808672,0.00002167341,0.8749117,0.0004869847,0.001571383,0.0001258302],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947395,0.002362314,0.00004387436,0.001938445,0.0004582176,0.0003454879,0.000005853952,0.00001144858,0.00009490335],"genre_scores_gemma":[0.9989609,0.0007207117,0.0000223671,0.0001228549,0.000009532438,0.000006733611,0.000001163774,0.00001677322,0.0001390291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1177872,"threshold_uncertainty_score":0.5351831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006351822160567649,"score_gpt":0.2307857867030808,"score_spread":0.2244339645425132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}