{"id":"W1856761374","doi":"10.2147/dddt.s88845","title":"Paget’s disease of bone: an osteoimmunological disorder?","year":2015,"lang":"en","type":"review","venue":"Drug Design Development and Therapy","topic":"Bone health and treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Amgen Canada; Université Laval; Arthritis Society; Eli Lilly and Company; Amgen","keywords":"Osteoimmunology; RANKL; Osteoprotegerin; Medicine; Immunology; Proinflammatory cytokine; Osteoclast; Bone disease; Osteoporosis; Bone resorption; Cancer research; Pathology; Internal medicine; Inflammation; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00017238,0.0006044973,0.001148926,0.000877648,0.0006766755,0.001111114,0.0004405643,0.002149963,0.005553968],"category_scores_gemma":[0.0005648367,0.0001637599,0.000238453,0.001086153,0.001676084,0.001090515,0.000471986,0.0007990112,0.001369273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004270143,"about_ca_system_score_gemma":0.0004772732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079622,"about_ca_topic_score_gemma":0.001298448,"domain_scores_codex":[0.9998624,0.00001527695,0.00002185985,0.00003176694,0.00003377537,0.00003501372],"domain_scores_gemma":[0.9998279,0.00002857716,0.00006385778,0.000008890035,0.00002785239,0.00004292289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006742565,0.000291469,0.03627069,0.004901035,0.0001627467,0.4353251,0.001037756,0.0001820927,0.02358023,0.03293965,0.04426143,0.4203735],"study_design_scores_gemma":[0.00008039246,0.0002085803,0.01542108,0.001006008,0.0001417754,0.8089406,0.001007381,0.000501286,0.003398507,0.01291617,0.1563228,0.00005539438],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1878046,0.691036,0.006794685,0.05183787,0.00467758,0.0001522629,0.0004718009,0.0003410583,0.05688423],"genre_scores_gemma":[0.7167,0.2318025,0.004625227,0.01116808,0.008808907,0.00009024554,0.0003724101,0.00005506344,0.02637751],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005553968,"threshold_uncertainty_score":0.01857984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1686114903308565,"score_gpt":0.3773982073769787,"score_spread":0.2087867170461221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}