{"id":"W1856761374","doi":"10.2147/dddt.s88845","title":"Paget’s disease of bone: an osteoimmunological disorder?","year":2015,"lang":"en","type":"review","venue":"Drug Design Development and Therapy","topic":"Bone health and treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec","funders":"Amgen Canada; Université Laval; Arthritis Society; Eli Lilly and Company; Amgen","keywords":"Osteoimmunology; RANKL; Osteoprotegerin; Medicine; Immunology; Proinflammatory cytokine; Osteoclast; Bone disease; Osteoporosis; Bone resorption; Cancer research; Pathology; Internal medicine; Inflammation; Receptor; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005872641,0.0005305461,0.001891235,0.0002168758,0.0001158348,0.00002037857,0.0001134499,0.0002342747,0.0000715726],"category_scores_gemma":[0.00002881555,0.0003390367,0.0001740171,0.0002262348,0.0001025319,0.00006623996,0.00004196507,0.0002689239,0.00005936933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008610921,"about_ca_system_score_gemma":0.001649606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001686461,"about_ca_topic_score_gemma":0.000002814469,"domain_scores_codex":[0.9976687,0.000314498,0.0007768862,0.0004953477,0.000355155,0.0003894011],"domain_scores_gemma":[0.9984581,0.0001085595,0.0003193387,0.0004283627,0.0001003867,0.0005852179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004294295,0.0005867855,0.0005312226,0.002444838,0.0003071871,0.00006298621,0.000402083,2.610488e-8,3.210901e-7,0.00001815061,0.0002527687,0.9949642],"study_design_scores_gemma":[0.002106206,0.0002398363,0.0008436566,0.002458417,0.0003439553,0.000034642,0.00001821643,7.158069e-7,0.000003414186,0.000110482,0.9935041,0.0003363614],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00265901,0.99485,0.00008503209,0.00006130933,0.0001108872,0.00206244,0.00001534175,0.00007174003,0.00008426065],"genre_scores_gemma":[0.000332718,0.9929274,0.00369025,0.0001020359,0.00003252875,0.0003279985,0.0006728865,0.00006256801,0.001851671],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9946278,"threshold_uncertainty_score":0.9999062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1686114903308565,"score_gpt":0.3773982073769787,"score_spread":0.2087867170461221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}