{"id":"W1856900646","doi":"10.1186/s13075-015-0741-z","title":"Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials","year":2015,"lang":"en","type":"article","venue":"Arthritis Research & Therapy","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"SUNY Downstate Medical Center; University of North Carolina at Chapel Hill; School of Medicine, New York University; York University; Anthera; Amgen; Cedars-Sinai Medical Center; University of Pittsburgh; State University of New York; University of Southern California","keywords":"Medicine; Rheumatology; Internal medicine; Double blind; Antagonist; B-cell activating factor; Randomized controlled trial; Physical therapy; Immunology; Placebo; Alternative medicine; Antibody; Pathology; Receptor; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002273722,0.0006221057,0.00135569,0.000233439,0.0002444501,0.0006805813,0.0003398815,0.0007415991,0.002048539],"category_scores_gemma":[0.001250212,0.0002514705,0.001045064,0.000305544,0.0005137569,0.0004941795,0.0001433132,0.001506233,0.0003529971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000415597,"about_ca_system_score_gemma":0.0005720516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003014555,"about_ca_topic_score_gemma":0.0007438769,"domain_scores_codex":[0.9995147,0.000256115,0.00006183988,0.00006897804,0.00005781448,0.00004059874],"domain_scores_gemma":[0.9991958,0.000265128,0.0002680525,0.00004142133,0.00007304877,0.0001567228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5774976,0.01351504,0.007775271,0.005332337,0.00552053,0.0001396857,0.0002115719,0.0008880916,0.03289788,0.0002464564,0.004014306,0.3519612],"study_design_scores_gemma":[0.7123788,0.2469467,0.02535424,0.0005642184,0.002896898,0.0004519545,0.00007046032,0.0006447714,0.004019847,0.0002728954,0.006360434,0.00003879561],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9280991,0.06537129,0.0008494817,0.001320723,0.0002600313,0.001149579,0.0006525742,0.0001262341,0.002171076],"genre_scores_gemma":[0.969971,0.02391388,0.001423241,0.001639008,0.0003116819,0.0008123124,0.000986094,0.00001716066,0.0009255345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002273722,"threshold_uncertainty_score":0.01202476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08287231878034751,"score_gpt":0.3569021099913607,"score_spread":0.2740297912110132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}