{"id":"W1858218191","doi":"10.1523/jneurosci.23-11-04437.2003","title":"Differential Frequency Dependence of P2Y<sub>1</sub>- and P2Y<sub>2</sub>- Mediated Ca<sup>2</sup><sup>+</sup>Signaling in Astrocytes","year":2003,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"P2Y receptor; Astrocyte; Extracellular; Stimulation; Purinergic receptor; Signal transduction; Receptor; Intracellular; Second messenger system; Biology; Cell biology; Phospholipase C; Neuroscience; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008666362,0.0001753012,0.0001999669,0.0001474347,0.00008342958,0.0001668396,0.0001634349,0.0002489013,0.001055348],"category_scores_gemma":[0.000252079,0.0001271079,0.0001489491,0.00007661912,0.0001803003,0.0002267111,0.0001703239,0.0003418378,0.0002170768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001841101,"about_ca_system_score_gemma":0.00008726036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004207206,"about_ca_topic_score_gemma":0.0004826132,"domain_scores_codex":[0.9998698,0.00001338986,0.00001069689,0.00002003775,0.00005055079,0.0000354108],"domain_scores_gemma":[0.9998807,0.00003407006,0.00003036807,0.00001136842,0.00001900436,0.00002453471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347051,0.000007923549,0.0001799076,0.00002033024,0.000002212836,0.00004844194,0.00001459222,0.00003709811,0.9986876,0.00005848326,0.00001921019,0.0007895217],"study_design_scores_gemma":[0.0000333241,0.000282506,0.05678516,0.00000830731,0.0000158993,0.0006629624,0.00005925996,0.003615035,0.9374131,0.0002161088,0.0008971101,0.00001130638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964113,0.0007996117,0.001272949,0.00007211659,0.00001122423,0.00001342206,0.0001564485,0.00002592325,0.001237147],"genre_scores_gemma":[0.9982101,0.0003664493,0.0005397625,0.00004600485,0.0000142662,0.00003501434,0.0001267091,0.000009783666,0.0006518181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001055348,"threshold_uncertainty_score":0.003530502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192628398252845,"score_gpt":0.2312570292665881,"score_spread":0.2193307452840596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}