{"id":"W1858218191","doi":"10.1523/jneurosci.23-11-04437.2003","title":"Differential Frequency Dependence of P2Y<sub>1</sub>- and P2Y<sub>2</sub>- Mediated Ca<sup>2</sup><sup>+</sup>Signaling in Astrocytes","year":2003,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"P2Y receptor; Astrocyte; Extracellular; Stimulation; Purinergic receptor; Signal transduction; Receptor; Intracellular; Second messenger system; Biology; Cell biology; Phospholipase C; Neuroscience; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000583538,0.0003794158,0.0005249813,0.0003037942,0.0001664458,0.0000815552,0.000578439,0.0002275374,0.00001250686],"category_scores_gemma":[0.001059527,0.0003410736,0.000192426,0.0005268237,0.0003430328,0.00007948846,0.0001444468,0.0005426251,0.000002362504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003775592,"about_ca_system_score_gemma":0.0003627461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001714329,"about_ca_topic_score_gemma":0.000005043341,"domain_scores_codex":[0.9967665,0.000297737,0.001006237,0.0005993914,0.0007100018,0.0006201093],"domain_scores_gemma":[0.9983139,0.0001425551,0.0006243064,0.0003195954,0.0002818533,0.0003177722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009147592,0.000136144,0.00671378,0.0000379401,0.00001701157,0.000137499,0.0001827153,0.0104866,0.9817623,0.00002341147,0.0001537687,0.0002573427],"study_design_scores_gemma":[0.001159767,0.0006991783,0.002855693,0.0001448336,0.00004898246,0.0006516295,0.0002251019,0.003840086,0.9898155,0.00009329359,0.0001256938,0.0003402434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954212,0.001511993,0.002553771,0.00007262483,0.0002114715,0.0001516707,0.00002149476,0.000008254053,0.00004749215],"genre_scores_gemma":[0.9980175,0.001065439,0.0003568225,0.0002689776,0.0002358571,0.000005033178,0.000006916949,0.00003383179,0.000009571669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008053182,"threshold_uncertainty_score":0.9999042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192628398252845,"score_gpt":0.2312570292665881,"score_spread":0.2193307452840596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}