{"id":"W1858288964","doi":"10.1039/c5dt02021b","title":"Albumin binding and ligand-exchange processes of the Ru(<scp>iii</scp>) anticancer agent NAMI-A and its bis-DMSO analogue determined by ENDOR spectroscopy","year":2015,"lang":"en","type":"article","venue":"Dalton Transactions","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burnaby Hospital; Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Imidazole; Histidine; Human serum albumin; Electron paramagnetic resonance; Ruthenium; Ligand (biochemistry); Stereochemistry; Medicinal chemistry; Crystallography; Amino acid; Organic chemistry; Nuclear magnetic resonance; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001434083,0.0001786695,0.0001809227,0.0001015945,0.00007986158,0.0001794975,0.0002430404,0.0002057067,0.0009382702],"category_scores_gemma":[0.0002821177,0.00009410039,0.00008713936,0.000102211,0.0001479891,0.0001165278,0.0001047099,0.0002665788,0.0003045947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184036,"about_ca_system_score_gemma":0.00008523459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001085632,"about_ca_topic_score_gemma":0.0006532229,"domain_scores_codex":[0.9998825,0.00003850069,0.000004512983,0.00002362004,0.00002679717,0.00002405331],"domain_scores_gemma":[0.9998984,0.00003415382,0.00002670838,0.000006244895,0.00002025943,0.00001422031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002193846,0.00002253055,0.0002042506,0.0000242922,0.000007439586,0.00003231818,0.00002831019,0.0001592417,0.9975859,0.00007149741,0.00004228642,0.001602508],"study_design_scores_gemma":[0.00001642548,0.00031964,0.004542559,0.00000241416,0.00001135992,0.00009898436,0.00002727688,0.005438505,0.9883506,0.00003894001,0.001144749,0.000008690101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963973,0.0005120697,0.002122899,0.00002816867,0.000004792476,0.000007932035,0.00007912276,0.00004323055,0.0008044931],"genre_scores_gemma":[0.997225,0.0001740311,0.001263282,0.00002121101,0.000003243267,0.000008158606,0.0001291672,0.00001289616,0.001163145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085632,"threshold_uncertainty_score":0.00313884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166203991781884,"score_gpt":0.2653949789027394,"score_spread":0.2487745797245511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}