{"id":"W1858521883","doi":"10.1039/c5sc01958c","title":"Mechanistic investigation of aziridine aldehyde-driven peptide macrocyclization: the imidoanhydride pathway","year":2015,"lang":"en","type":"article","venue":"Chemical Science","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada); University of Toronto; Toronto Public Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Genomics Institute; Québec Consortium for Drug Discovery; Ontario Genomics","keywords":"Aziridine; Aldehyde; Peptide; Chemistry; Combinatorial chemistry; Stereochemistry; Biochemistry; Organic chemistry; Catalysis; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002442328,0.0004005719,0.0002266376,0.00017318,0.0002149505,0.0002515736,0.0003289159,0.0002491351,0.001313412],"category_scores_gemma":[0.0002128658,0.0001185665,0.0001691164,0.00009722872,0.0003284812,0.000400151,0.0002237308,0.0004273252,0.0002427674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003976748,"about_ca_system_score_gemma":0.0003559106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526146,"about_ca_topic_score_gemma":0.001128175,"domain_scores_codex":[0.9998844,0.00001814614,0.0000054637,0.00002905226,0.00002744748,0.00003553127],"domain_scores_gemma":[0.9999137,0.00002464535,0.00002127299,0.00001021382,0.00001350992,0.00001670599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002238915,0.00007862989,0.0007847087,0.0001241601,0.00002328506,0.0004621402,0.000141551,0.00156559,0.9883812,0.002387731,0.00008341565,0.005743701],"study_design_scores_gemma":[0.00001372225,0.0003036889,0.00187327,0.000004510014,0.0000154199,0.000253431,0.00004307594,0.00305234,0.9925564,0.0002268156,0.00164608,0.00001130531],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862416,0.001227015,0.006634301,0.0001038479,0.00001847161,0.0001208354,0.0001201396,0.00006842344,0.005465287],"genre_scores_gemma":[0.9966804,0.0004234762,0.002165562,0.00002278253,0.000003949092,0.00002232264,0.0000326856,0.000006435085,0.0006423564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313412,"threshold_uncertainty_score":0.004393816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03435325187586951,"score_gpt":0.2480101600928251,"score_spread":0.2136569082169556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}