{"id":"W1860539167","doi":"10.1371/journal.pone.0139317","title":"ITPA Polymorphisms Are Associated with Hematological Side Effects during Antiviral Therapy for Chronic HCV Infection","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Stichting voor Lever- en Maag-Darm Onderzoek; Virgo Consortium; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"ITPA; Ribavirin; Medicine; Internal medicine; Erythropoietin; Gastroenterology; Inosine monophosphate; Anemia; Hepatitis C virus; Immunology; Biology; Virus; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004898945,0.000263161,0.0002843956,0.0002225561,0.000184366,0.00034105,0.0001540938,0.0002918507,0.001304087],"category_scores_gemma":[0.0017613,0.0001366706,0.0004032869,0.0004228921,0.0001631402,0.0001452152,0.0001347587,0.000472698,0.0001086743],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001644383,"about_ca_system_score_gemma":0.0001317091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032748,"about_ca_topic_score_gemma":0.001383403,"domain_scores_codex":[0.9996319,0.0001339732,0.0000506593,0.00006771126,0.00007259261,0.00004315531],"domain_scores_gemma":[0.9980184,0.0004508619,0.001213886,0.00007920252,0.00009601527,0.0001416329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005101581,0.00003082917,0.9956814,0.000008628715,0.00009943489,0.0001172651,0.00002889906,0.00009377192,0.001457275,0.00001106996,0.00004054622,0.001920701],"study_design_scores_gemma":[0.00001391697,0.0001589556,0.9982363,0.000005505672,0.00005844796,0.0006512325,0.00002049454,0.0004966059,0.000253976,0.00001694634,0.0000848167,0.000002781597],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994504,0.0002136225,0.00009140107,0.00002461514,0.000003314688,0.00000286066,0.00006709722,0.0000022466,0.0001444958],"genre_scores_gemma":[0.9997953,0.00002861152,0.00005763943,0.00001083227,0.000005145873,0.000001780423,0.0000532887,0.000001077217,0.00004640725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001304087,"threshold_uncertainty_score":0.004362643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713199484192907,"score_gpt":0.2559476589762634,"score_spread":0.2188156641343343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}