{"id":"W1860539167","doi":"10.1371/journal.pone.0139317","title":"ITPA Polymorphisms Are Associated with Hematological Side Effects during Antiviral Therapy for Chronic HCV Infection","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Stichting voor Lever- en Maag-Darm Onderzoek; Virgo Consortium; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb","keywords":"ITPA; Ribavirin; Medicine; Internal medicine; Erythropoietin; Gastroenterology; Inosine monophosphate; Anemia; Hepatitis C virus; Immunology; Biology; Virus; Nucleotide; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208834,0.0001549484,0.0002143216,0.00003041368,0.00007231354,0.00002373132,0.0001042336,0.0002156936,0.000002439903],"category_scores_gemma":[0.0003160023,0.0001199787,0.00007310736,0.00009738759,0.00008467226,0.000004291877,0.00007139667,0.0001272635,0.000006605925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004936863,"about_ca_system_score_gemma":0.00007393478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001032149,"about_ca_topic_score_gemma":0.0000246066,"domain_scores_codex":[0.9989092,0.0000706279,0.0001112115,0.0003309189,0.0002358524,0.0003421547],"domain_scores_gemma":[0.9994388,0.00002041258,0.00006928327,0.000198177,0.0001528596,0.0001205324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004260045,0.0007983942,0.0100272,0.00007185899,0.0002676408,0.00001155908,0.000007458403,0.000001395973,0.9880111,0.000008985662,0.0001013146,0.0002670419],"study_design_scores_gemma":[0.002391543,0.001520497,0.00929739,0.0001159467,0.00003075668,0.000004451115,0.000002720151,0.00003917951,0.9862294,0.00004930139,0.0001316398,0.0001871827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977166,0.0009844711,0.0002367893,0.0001975822,0.00002002004,0.0005407833,0.000009543257,0.00003686026,0.0002573251],"genre_scores_gemma":[0.9987363,0.0001096462,0.0001785725,0.000100906,0.0001672163,0.0001602191,0.0001365229,0.00002928419,0.0003813144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001965538,"threshold_uncertainty_score":0.4892588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03713199484192907,"score_gpt":0.2559476589762634,"score_spread":0.2188156641343343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}