{"id":"W1860699668","doi":"10.1039/c5nr01483b","title":"Induction of apoptosis in human cancer cells by targeting mitochondria with gold nanoparticles","year":2015,"lang":"en","type":"article","venue":"Nanoscale","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"Institute of Genetics; Leibniz-Institut für Polymerforschung Dresden; Bundesministerium für Bildung und Forschung; Cape Breton University; Edgewood Chemical Biological Center; Leibniz-Gemeinschaft; Technische Universität Dresden; Deutsche Forschungsgemeinschaft; Friedrich-Schiller-Universität Jena","keywords":"Mitochondrion; Colloidal gold; Apoptosis; Cancer cell; Endosome; Conjugated system; Nanoparticle; Chemistry; Dendrimer; Nanotechnology; Biophysics; Cancer; Cell; Materials science; Cell biology; Biochemistry; Biology; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009979052,0.0001004231,0.0001383801,0.00003875618,0.0000219395,0.000007108895,0.00007616139,0.0001086913,0.00000101238],"category_scores_gemma":[0.00001513847,0.00008073441,0.00003288724,0.0001621023,0.00007919771,0.000005181407,0.0000313965,0.00005766453,3.795191e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002178503,"about_ca_system_score_gemma":0.00002704459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002070781,"about_ca_topic_score_gemma":0.0001348755,"domain_scores_codex":[0.9992871,0.00003715543,0.0001802805,0.0002270403,0.0001158853,0.000152588],"domain_scores_gemma":[0.999602,0.000002811033,0.0001006913,0.0001511153,0.00009187368,0.00005155945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004395488,0.00006856862,0.002616019,0.000006070683,0.00001354037,2.595979e-7,0.00002912087,0.00002338107,0.9873743,0.000001996312,0.009211438,0.000611375],"study_design_scores_gemma":[0.0003178298,0.0002100755,0.00006258512,0.00002375481,0.00001560805,6.016816e-7,0.0001248524,0.000008932533,0.9952165,0.00001971784,0.003881788,0.0001177496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991937,0.0003347815,0.0001071385,0.00006356275,0.00004687211,0.00008515203,0.00001336623,0.00001502997,0.0001404492],"genre_scores_gemma":[0.9966735,0.0000629732,0.002716438,0.00004037256,0.0000663114,0.00001260028,0.00003807715,0.00001244069,0.0003772649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007842229,"threshold_uncertainty_score":0.3292254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161421175947393,"score_gpt":0.2676078949441404,"score_spread":0.2559936831846665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}