{"id":"W1860699668","doi":"10.1039/c5nr01483b","title":"Induction of apoptosis in human cancer cells by targeting mitochondria with gold nanoparticles","year":2015,"lang":"en","type":"article","venue":"Nanoscale","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"Institute of Genetics; Leibniz-Institut für Polymerforschung Dresden; Bundesministerium für Bildung und Forschung; Cape Breton University; Edgewood Chemical Biological Center; Leibniz-Gemeinschaft; Technische Universität Dresden; Deutsche Forschungsgemeinschaft; Friedrich-Schiller-Universität Jena","keywords":"Mitochondrion; Colloidal gold; Apoptosis; Cancer cell; Endosome; Conjugated system; Nanoparticle; Chemistry; Dendrimer; Nanotechnology; Biophysics; Cancer; Cell; Materials science; Cell biology; Biochemistry; Biology; Organic chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001846982,0.0002515638,0.0001999965,0.0001429163,0.0001267199,0.0001793625,0.0001476625,0.0002641905,0.0003834972],"category_scores_gemma":[0.0001611807,0.0001212949,0.0001792772,0.0001099372,0.0001729493,0.0001161262,0.0001791552,0.0003022977,0.0001830795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000315418,"about_ca_system_score_gemma":0.0001569758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003957509,"about_ca_topic_score_gemma":0.0004676703,"domain_scores_codex":[0.9998807,0.00002803158,0.00000907562,0.00002548422,0.00003626507,0.00002046637],"domain_scores_gemma":[0.999939,0.00001969131,0.00001376106,0.000009822693,0.00001142042,0.000006344415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000383507,0.0000135478,0.00007652739,0.00003482097,0.000002934585,0.00004136856,0.0000178478,0.00006628328,0.9982312,0.000103471,0.00002960247,0.001344054],"study_design_scores_gemma":[0.000004563727,0.00008952859,0.0002390785,0.000001929645,0.000003143758,0.00008735039,0.000004027794,0.0002343868,0.9985077,0.0000234688,0.0008037957,0.000001104577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711973,0.00428878,0.02068953,0.0002523749,0.00004474489,0.00008798536,0.0001123092,0.0003030909,0.00302379],"genre_scores_gemma":[0.9853735,0.001812263,0.01004816,0.00009221639,0.00001089066,0.00005005501,0.0001392905,0.00002093628,0.002452738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003957509,"threshold_uncertainty_score":0.00228852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161421175947393,"score_gpt":0.2676078949441404,"score_spread":0.2559936831846665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}