{"id":"W186075104","doi":"","title":"Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.","year":2007,"lang":"en","type":"article","venue":"PubMed","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Ribavirin; Allosteric regulation; Nucleoside; Polymerase; RNA polymerase; Virology; Hepatitis C virus; Medicine; Pharmacology; Enzyme; Biology; RNA; Virus; Hepacivirus; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000774772,0.0005439698,0.0004655005,0.0004902831,0.0001874661,0.000623462,0.0004169241,0.0005173847,0.003863259],"category_scores_gemma":[0.0003521303,0.0001879701,0.0002826705,0.0004263826,0.0003154546,0.0008001358,0.0004271975,0.001033466,0.001920457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005414005,"about_ca_system_score_gemma":0.0007829104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005538891,"about_ca_topic_score_gemma":0.001453346,"domain_scores_codex":[0.9997597,0.00003258386,0.00001343279,0.00003446862,0.0001355305,0.00002421613],"domain_scores_gemma":[0.9998062,0.00004773869,0.000043166,0.00001550388,0.00004709113,0.00004031546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005953629,0.0003715641,0.0006366434,0.0028904,0.00006306461,0.0001756363,0.00007708982,0.0004388872,0.1774669,0.006602047,0.009428072,0.8012543],"study_design_scores_gemma":[0.0003053574,0.002048835,0.005603142,0.0006066072,0.0002315966,0.00307168,0.00007993786,0.00257991,0.2331975,0.003938471,0.7482582,0.00007875207],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02051359,0.9562663,0.01037567,0.002099663,0.0006349496,0.00007576911,0.0002170125,0.0001756618,0.00964132],"genre_scores_gemma":[0.1004089,0.8630342,0.0190612,0.001140121,0.0005300181,0.00006368045,0.0007210654,0.00004786907,0.01499287],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003863259,"threshold_uncertainty_score":0.01292384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305496010922837,"score_gpt":0.2790452962484534,"score_spread":0.255990336139225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}