{"id":"W186075104","doi":"","title":"Non-nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections.","year":2007,"lang":"en","type":"article","venue":"PubMed","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Ribavirin; Allosteric regulation; Nucleoside; Polymerase; RNA polymerase; Virology; Hepatitis C virus; Medicine; Pharmacology; Enzyme; Biology; RNA; Virus; Hepacivirus; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003222609,0.00008362699,0.0001004568,0.00002695903,0.00005411751,0.000008202606,0.0001579689,0.0000661871,3.385414e-7],"category_scores_gemma":[0.000032041,0.00004134392,0.00007670045,0.000113738,0.0002187028,0.000002650992,0.00007659787,0.00003835782,2.817068e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001408428,"about_ca_system_score_gemma":0.00004872612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003910248,"about_ca_topic_score_gemma":0.00009902007,"domain_scores_codex":[0.999273,0.00001568036,0.0002282164,0.0001385078,0.0001475426,0.0001970651],"domain_scores_gemma":[0.9995857,0.00003822584,0.00008931833,0.0002175472,0.00004126666,0.00002792853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005251787,0.002729005,0.1217971,0.0001812522,0.0003541911,9.150573e-7,0.00104032,0.000006577875,0.2920339,0.00009658264,0.0002347808,0.5810002],"study_design_scores_gemma":[0.000678887,0.00008211951,0.2325525,0.000008143594,0.00001390892,0.000001058094,0.00009892372,0.000003046261,0.759406,0.000003134306,0.007109916,0.00004245625],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967774,0.001373532,0.000394839,0.0002351341,0.00004885151,0.001072067,0.00001649167,8.589797e-7,0.00008081055],"genre_scores_gemma":[0.9991418,0.00009342383,0.0001079581,0.00004157,0.00003637777,0.0004885966,0.00001207135,0.000007350717,0.00007091503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5809578,"threshold_uncertainty_score":0.1685956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305496010922837,"score_gpt":0.2790452962484534,"score_spread":0.255990336139225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}