{"id":"W1861748936","doi":"10.1158/1078-0432.ccr-15-0468","title":"Preclinical Efficacy and Safety Assessment of an Antibody–Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Takeda Pharmaceuticals International","keywords":"Breast cancer; Medicine; Antibody-drug conjugate; Cancer; Cancer research; Tissue microarray; Antibody; Immunohistochemistry; Cytotoxic T cell; Pharmacology; Pathology; Internal medicine; Monoclonal antibody; Immunology; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.03278156,0.0002612724,0.0009780125,0.000154807,0.0003222555,0.00009018418,0.0007430163,0.0002730656,0.0002444171],"category_scores_gemma":[0.006322674,0.0001734491,0.0002317522,0.000577134,0.002200081,0.0001374034,0.000636213,0.002164004,0.00001136303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003840755,"about_ca_system_score_gemma":0.005600321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009771547,"about_ca_topic_score_gemma":0.0001560608,"domain_scores_codex":[0.9915965,0.002436639,0.001648527,0.001050958,0.002176191,0.001091168],"domain_scores_gemma":[0.9888663,0.005786024,0.0002523708,0.001134667,0.002650392,0.001310293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02290615,0.002251264,0.7907888,0.001585939,0.000417788,0.00009108015,0.0008002835,0.00004924801,0.006313026,0.0005902422,0.01982622,0.15438],"study_design_scores_gemma":[0.03143685,0.01178865,0.8400109,0.001201434,0.0002516979,0.0001110453,0.001429981,0.01693227,0.0043891,0.0009104755,0.09092405,0.0006135251],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729683,0.001831011,0.0001302281,0.01514843,0.000386974,0.007891404,0.0003599366,0.00004570695,0.001237968],"genre_scores_gemma":[0.9928663,0.0008125356,0.002131797,0.0003159737,0.002022261,0.001112896,0.00008075198,0.00008566873,0.0005717897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1537665,"threshold_uncertainty_score":0.9959549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3735274212817079,"score_gpt":0.6302471702096378,"score_spread":0.2567197489279299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}