{"id":"W1861748936","doi":"10.1158/1078-0432.ccr-15-0468","title":"Preclinical Efficacy and Safety Assessment of an Antibody–Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma","year":2015,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Takeda Pharmaceuticals International","keywords":"Breast cancer; Medicine; Antibody-drug conjugate; Cancer; Cancer research; Tissue microarray; Antibody; Immunohistochemistry; Cytotoxic T cell; Pharmacology; Pathology; Internal medicine; Monoclonal antibody; Immunology; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005635784,0.0004691269,0.000373079,0.0003717811,0.0001952258,0.0003074431,0.0003706805,0.0003999403,0.001115245],"category_scores_gemma":[0.0004096962,0.000153462,0.0002579695,0.0002186273,0.000258955,0.0002687653,0.0001306229,0.0005080611,0.0002940553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005832207,"about_ca_system_score_gemma":0.0006408173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749359,"about_ca_topic_score_gemma":0.0008782708,"domain_scores_codex":[0.9998156,0.00005779957,0.00001146963,0.00002591889,0.00005623774,0.00003293776],"domain_scores_gemma":[0.9997559,0.0000416986,0.0000817385,0.00002577211,0.00005790763,0.00003695073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002588514,0.002472882,0.001361173,0.0001773525,0.00005745933,0.000096966,0.00006375775,0.001899981,0.9731547,0.0001328684,0.000272211,0.01772226],"study_design_scores_gemma":[0.0005019975,0.05262861,0.003650315,0.00001574914,0.000117596,0.0003423616,0.00003102162,0.003191218,0.9369597,0.00004715558,0.002504646,0.000009592937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954052,0.0009957169,0.001866212,0.00007696208,0.0000219262,0.0003347478,0.0002275174,0.0000493117,0.001022333],"genre_scores_gemma":[0.9958867,0.000858731,0.001722597,0.00003569059,0.00001998217,0.0001442395,0.0003506744,0.00001195111,0.0009693019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001115245,"threshold_uncertainty_score":0.004231572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3735274212817079,"score_gpt":0.6302471702096378,"score_spread":0.2567197489279299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}