{"id":"W1861794262","doi":"10.1039/c5gc00659g","title":"A multigram-scale lower E-factor procedure for MIBA-catalyzed direct amidation and its application to the coupling of alpha and beta aminoacids","year":2015,"lang":"en","type":"article","venue":"Green Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"BETA (programming language); Alpha (finance); Chemistry; Catalysis; Scale (ratio); Coupling (piping); Combinatorial chemistry; Organic chemistry; Computational chemistry; Physics; Materials science; Computer science; Mathematics; Programming language; Metallurgy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001065461,0.0001086187,0.000141331,0.000007547245,0.000041009,0.00001309938,0.0001051761,0.0001089885,0.000002599464],"category_scores_gemma":[0.00009449261,0.0000837082,0.00005154049,0.00006284886,0.00003664681,0.000003674835,0.00006910542,0.00003367136,6.414818e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008577591,"about_ca_system_score_gemma":0.00001974665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002456032,"about_ca_topic_score_gemma":0.00002646536,"domain_scores_codex":[0.9993545,0.000002976933,0.000150253,0.0002888643,0.00008947153,0.0001139582],"domain_scores_gemma":[0.999499,0.00001806836,0.00007932746,0.0001892523,0.0001123099,0.0001020299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005717873,0.00002851381,0.002156736,0.0000883688,0.00003640995,4.423339e-8,0.00004744323,0.000009436686,0.9948283,5.226433e-7,0.0001180612,0.002628983],"study_design_scores_gemma":[0.0002842528,0.00002081731,0.0007407842,0.00001371877,0.00005230568,0.000001663358,0.00005931457,0.002270442,0.9929445,0.000005688716,0.003494778,0.0001117453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980425,0.0006711158,0.0005737283,0.0003215682,0.000007102926,0.0002167143,0.00008939177,0.000006630283,0.00007123466],"genre_scores_gemma":[0.9990932,0.00003627102,0.000177325,0.00003175848,0.000132706,0.00007822267,0.0001714426,0.0000113521,0.0002677217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003376717,"threshold_uncertainty_score":0.3413521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119190642013551,"score_gpt":0.2440857264040599,"score_spread":0.2321666622027048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}