{"id":"W1861794262","doi":"10.1039/c5gc00659g","title":"A multigram-scale lower E-factor procedure for MIBA-catalyzed direct amidation and its application to the coupling of alpha and beta aminoacids","year":2015,"lang":"en","type":"article","venue":"Green Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Hospital Edmonton; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"BETA (programming language); Alpha (finance); Chemistry; Catalysis; Scale (ratio); Coupling (piping); Combinatorial chemistry; Organic chemistry; Computational chemistry; Physics; Materials science; Computer science; Mathematics; Programming language; Metallurgy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007067864,0.0009348401,0.000447745,0.000833301,0.000401935,0.0002685929,0.0006220064,0.0006362691,0.007945583],"category_scores_gemma":[0.0006216428,0.000351932,0.0003623865,0.0006211832,0.000267776,0.0004992125,0.0003638453,0.001517885,0.004141433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002545391,"about_ca_system_score_gemma":0.0004538716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005658112,"about_ca_topic_score_gemma":0.001432287,"domain_scores_codex":[0.9996557,0.00007981251,0.00003065097,0.00008658529,0.00008272566,0.00006450594],"domain_scores_gemma":[0.9996353,0.00010319,0.0000575671,0.0001039087,0.00005781936,0.00004224922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009836578,0.00004633567,0.00008877672,0.00009814445,0.00001463886,0.0001002473,0.00002636906,0.0001171684,0.9847017,0.0003491686,0.0003884128,0.01397055],"study_design_scores_gemma":[0.00002034597,0.0002758159,0.001088884,0.000009439837,0.00001777502,0.0004393019,0.00001664629,0.0004001406,0.9884063,0.0001185611,0.009186883,0.000019883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3938928,0.005792943,0.5782208,0.0009997244,0.000430576,0.000772231,0.001963524,0.003213784,0.01471354],"genre_scores_gemma":[0.5086379,0.004082731,0.457006,0.000435074,0.0001179327,0.0009336857,0.003460441,0.0005356623,0.02479048],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.007945583,"threshold_uncertainty_score":0.02658069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119190642013551,"score_gpt":0.2440857264040599,"score_spread":0.2321666622027048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}