{"id":"W1862185568","doi":"10.1007/978-0-387-47257-7_4","title":"Fluorescence-Signaling Nucleic Acid-Based Sensors","year":2006,"lang":"en","type":"book-chapter","venue":"","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Deoxyribozyme; Aptamer; Molecular beacon; Ribozyme; Nucleic acid; Oligonucleotide; DNA; Computational biology; RNA; Combinatorial chemistry; Chemistry; Biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002597331,0.0007221843,0.0003808572,0.0003822644,0.0002572393,0.0007233091,0.001276504,0.0008281667,0.003312117],"category_scores_gemma":[0.0002065209,0.0003419749,0.000246354,0.0004762275,0.0004471541,0.001294653,0.0004905391,0.0009973011,0.004317114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006163592,"about_ca_system_score_gemma":0.0002519522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002327727,"about_ca_topic_score_gemma":0.0005456897,"domain_scores_codex":[0.9997302,0.00002325376,0.000008654843,0.00006192812,0.0001492776,0.00002655967],"domain_scores_gemma":[0.9999455,0.00001655597,0.000006306741,0.000005899956,0.0000169902,0.00000864909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005502461,0.00004430561,0.00004890034,0.0003272528,0.000009033653,0.00008411883,0.00008254691,0.0004989452,0.8857023,0.02159479,0.005087807,0.08646494],"study_design_scores_gemma":[0.000007451652,0.00006595244,0.0001396047,0.00002990262,0.000009519781,0.0003478028,0.00002812511,0.003321879,0.8759833,0.004157507,0.1158937,0.00001528255],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.07889097,0.09443929,0.6146867,0.002665257,0.00221713,0.0004204091,0.001160921,0.004157813,0.2013616],"genre_scores_gemma":[0.2756642,0.07469271,0.34646,0.003136758,0.0005497985,0.0004384647,0.001643418,0.0003896663,0.2970252],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003312117,"threshold_uncertainty_score":0.01108009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01077714495374728,"score_gpt":0.2391874106265256,"score_spread":0.2284102656727783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}