{"id":"W1863548789","doi":"10.2147/itt.s61528","title":"The hygiene hypothesis: current perspectives and future therapies","year":2015,"lang":"en","type":"review","venue":"ImmunoTargets and Therapy","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Child and Family Research Institute; University of British Columbia","funders":"University of British Columbia; Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Hygiene hypothesis; Immune system; Immunology; Disease; Immune dysregulation; Microbiome; Helminths; Inflammatory bowel disease; Gut flora; Immunity; Biology; Medicine; Bioinformatics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003347397,0.0003855902,0.0005891535,0.00003754386,0.0003591392,0.0001137002,0.0002229633,0.0002339765,0.000007070396],"category_scores_gemma":[0.000009317613,0.0002088824,0.0001720609,0.00005712032,0.0002065533,0.000003683436,0.00008561648,0.0002427305,0.000004198455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001715401,"about_ca_system_score_gemma":0.0002031644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007600746,"about_ca_topic_score_gemma":0.000004473495,"domain_scores_codex":[0.9987438,0.0001848497,0.0002615651,0.0004227705,0.00008544035,0.0003015134],"domain_scores_gemma":[0.9992138,0.00003160052,0.0001737242,0.0004097464,0.00009158402,0.00007955136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003375496,0.00003474052,0.000002410531,0.0002846014,0.0002347474,4.535815e-7,0.0003847847,2.740094e-9,0.0001658686,0.0001633904,0.0009668604,0.9977284],"study_design_scores_gemma":[0.0003201819,0.0001884694,0.00008321778,0.0002262579,0.00004669581,0.00003631386,0.0004259945,5.859279e-8,0.000008106746,0.0001251146,0.9982715,0.0002681348],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008033399,0.9979017,0.000001056195,0.0002585322,0.0004137646,0.0004715513,0.00004041551,0.00001102824,0.00009855308],"genre_scores_gemma":[0.00007250888,0.9985124,0.00004979326,0.00004722834,0.0009470994,0.00005777537,0.00004424718,0.00004960732,0.0002192827],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9974602,"threshold_uncertainty_score":0.8517977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03441472288045366,"score_gpt":0.3236658805536489,"score_spread":0.2892511576731953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}