{"id":"W1863548789","doi":"10.2147/itt.s61528","title":"The hygiene hypothesis: current perspectives and future therapies","year":2015,"lang":"en","type":"review","venue":"ImmunoTargets and Therapy","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Child and Family Research Institute; University of British Columbia","funders":"University of British Columbia; Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Hygiene hypothesis; Immune system; Immunology; Disease; Immune dysregulation; Microbiome; Helminths; Inflammatory bowel disease; Gut flora; Immunity; Biology; Medicine; Bioinformatics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005942571,0.001174718,0.002846069,0.001851076,0.000953509,0.004809593,0.003251408,0.007612016,0.01464454],"category_scores_gemma":[0.007182735,0.0004205191,0.001922718,0.001258298,0.003633581,0.006780028,0.002545266,0.01116027,0.00548483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001971527,"about_ca_system_score_gemma":0.004586054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006781,"about_ca_topic_score_gemma":0.002712843,"domain_scores_codex":[0.9983027,0.0006017894,0.0001697985,0.0002617328,0.0003787012,0.000285221],"domain_scores_gemma":[0.9931507,0.003230574,0.0005209725,0.000297284,0.001665564,0.001134916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000972975,0.0008731816,0.000946793,0.009475333,0.0002532458,0.001124374,0.0003325709,0.0007472412,0.001656756,0.04001733,0.1387524,0.8048478],"study_design_scores_gemma":[0.0002861779,0.0007551715,0.001176838,0.01043754,0.0002570555,0.001515859,0.001009736,0.0007766364,0.0005665928,0.07100689,0.9120995,0.0001119401],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005678732,0.9422362,0.001322545,0.04795675,0.003857062,0.00002753751,0.00008415452,0.00009370618,0.003854078],"genre_scores_gemma":[0.007452574,0.9512455,0.004233729,0.0217063,0.01179024,0.0001393165,0.0002594678,0.00003810561,0.003134672],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01464454,"threshold_uncertainty_score":0.04899085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03441472288045366,"score_gpt":0.3236658805536489,"score_spread":0.2892511576731953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}