{"id":"W1863660946","doi":"10.1152/ajpheart.2001.281.6.h2410","title":"Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system","year":2001,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Quinapril; Losartan; Internal medicine; Endocrinology; Angiotensin II; Renin–angiotensin system; Medicine; Losartan Potassium; Plasma renin activity; Muscle hypertrophy; Circulatory system; Left ventricular hypertrophy; Angiotensin-converting enzyme; Blood pressure; ACE inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003471595,0.0003560599,0.001222038,0.0001457253,0.0001354124,0.000009715397,0.0002629969,0.000253303,0.00002262853],"category_scores_gemma":[0.0000372865,0.0003208252,0.0006269379,0.0001906971,0.0004642183,0.00001809639,0.0001123022,0.0003138039,0.000006625057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000439119,"about_ca_system_score_gemma":0.000171693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000932206,"about_ca_topic_score_gemma":9.65484e-7,"domain_scores_codex":[0.997636,0.0004755557,0.0006477038,0.0005548452,0.0002084516,0.0004774111],"domain_scores_gemma":[0.9981459,0.0000585787,0.0007012828,0.0005465364,0.0003279667,0.0002196764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006973818,0.00005415567,0.001111617,0.00001688141,0.0005972387,6.57597e-7,0.00009146189,0.00008794186,0.9959558,0.0001409001,0.00009148548,0.001154503],"study_design_scores_gemma":[0.001676576,0.005121747,0.3960694,0.0000932888,0.0003477968,0.0001467514,0.001884739,0.00009126322,0.5857283,0.0002869556,0.007802872,0.0007503156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995861,0.002808983,0.000007077618,0.00003065422,0.001029416,0.0001659881,0.0000122514,0.00001413194,0.00007051351],"genre_scores_gemma":[0.998152,0.0002553666,0.0002869969,0.00009163081,0.001126909,0.000008916444,0.00002093494,0.00004919062,0.000008036335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4102275,"threshold_uncertainty_score":0.9999244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100458069126031,"score_gpt":0.2237990010085493,"score_spread":0.2137531940959462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}