{"id":"W1863671141","doi":"10.1158/1538-7445.am2014-2563","title":"Abstract 2563: Development of clinical assay to mitigate daratumumab, an IgG1κ monoclonal antibody, interference with serum immunofixation (IFE) and clinical assessment of M-protein response in multiple myeloma","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Daratumumab; Serum protein electrophoresis; Monoclonal antibody; Immunofixation; Medicine; Multiple myeloma; Antibody; Monoclonal; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002318705,0.00101181,0.0005164805,0.0008323538,0.0003494163,0.0006921455,0.0005349556,0.001274405,0.00196577],"category_scores_gemma":[0.002469351,0.000399021,0.0004157666,0.0003883305,0.0004475822,0.0002840667,0.0003949401,0.0007819616,0.001483742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004895948,"about_ca_system_score_gemma":0.0007984483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009701946,"about_ca_topic_score_gemma":0.00148103,"domain_scores_codex":[0.9975327,0.0005841777,0.0002261581,0.0003735444,0.001140389,0.0001429461],"domain_scores_gemma":[0.9991198,0.0001396895,0.0001692214,0.00006354377,0.0004132864,0.00009440377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002702735,0.0002468661,0.002542364,0.000186652,0.00002510224,0.00008189595,0.00006161777,0.000155976,0.9824246,0.000109604,0.0008266029,0.01306845],"study_design_scores_gemma":[0.0001071622,0.0015797,0.008279435,0.00005760392,0.00006159852,0.0009474995,0.00003572366,0.003391683,0.9765046,0.000083394,0.008924066,0.00002743423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8249958,0.01043623,0.1411121,0.002005709,0.0009889402,0.003970691,0.00220504,0.003105662,0.01117975],"genre_scores_gemma":[0.7820434,0.002179986,0.197392,0.001670147,0.0001712614,0.001547211,0.003718977,0.0002038121,0.01107317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002318705,"threshold_uncertainty_score":0.01226264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1760039852968031,"score_gpt":0.5321469711729264,"score_spread":0.3561429858761234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}