{"id":"W1864201055","doi":"10.1186/1471-2407-3-9","title":"Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells","year":2003,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Susan G. Komen for the Cure","keywords":"MCF-7; Progesterone receptor; Cell growth; Internal medicine; Chemistry; Cell culture; Endocrinology; Enzyme; Reductase; Hydroxysteroid; Estrogen; Oxidoreductase; Biology; Estrogen receptor; Cancer cell; Biochemistry; Breast cancer; Human breast; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003403111,0.0005790115,0.0007094053,0.0001928949,0.0002037158,0.00007302845,0.0001807986,0.000344316,0.00003256319],"category_scores_gemma":[0.00002683734,0.0005228095,0.000116561,0.0002480305,0.0004188296,0.00006399396,0.000197871,0.0003353044,0.000001190969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000739271,"about_ca_system_score_gemma":0.0002274547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007802212,"about_ca_topic_score_gemma":0.0005619961,"domain_scores_codex":[0.9970851,0.0003509503,0.0005556808,0.001060158,0.0002745089,0.0006736088],"domain_scores_gemma":[0.9986722,0.00003293075,0.0003713175,0.000507262,0.0000833256,0.0003329043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003018109,0.0002103481,0.01527308,0.0003645516,0.0001051132,0.00001560499,0.0002166373,0.00006239409,0.9824081,0.00002095201,0.0002211176,0.0008002744],"study_design_scores_gemma":[0.002453519,0.0002676839,0.014613,0.0003456762,0.0001752397,0.0002612711,0.0001865847,0.00003804256,0.980608,0.00003459332,0.0004232402,0.0005931163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9484355,0.04998565,0.00001539748,0.00003965162,0.0003163941,0.0008119571,0.0002972721,0.00002115829,0.00007702735],"genre_scores_gemma":[0.9937681,0.005051671,0.0002876609,0.00003953058,0.000217304,0.0002506151,0.00004892968,0.00008333111,0.0002528911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04533258,"threshold_uncertainty_score":0.9997224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087339792137457,"score_gpt":0.258556817897285,"score_spread":0.2504694781051475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}