{"id":"W1864201055","doi":"10.1186/1471-2407-3-9","title":"Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydroxysteroid oxidoreductase and 3α(β)-hydroxysteroid oxidoreductases in tumorigenic (MCF-7, MDA-MB-231, T-47D) and nontumorigenic (MCF-10A) human breast cancer cells","year":2003,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Susan G. Komen for the Cure","keywords":"MCF-7; Progesterone receptor; Cell growth; Internal medicine; Chemistry; Cell culture; Endocrinology; Enzyme; Reductase; Hydroxysteroid; Estrogen; Oxidoreductase; Biology; Estrogen receptor; Cancer cell; Biochemistry; Breast cancer; Human breast; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145268,0.0002152033,0.000254401,0.0002871354,0.0001963408,0.0002972423,0.0001274422,0.0002383162,0.0009485897],"category_scores_gemma":[0.0001323998,0.0001392019,0.000276662,0.000408524,0.0002007912,0.0002237769,0.0001101332,0.0002294993,0.0005024284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266407,"about_ca_system_score_gemma":0.0002129103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003201547,"about_ca_topic_score_gemma":0.002049195,"domain_scores_codex":[0.999864,0.00001419521,0.00001483602,0.0000437252,0.00003041486,0.00003293621],"domain_scores_gemma":[0.9999173,0.00001848061,0.00001466935,0.00001584371,0.00001915881,0.00001459102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000275836,0.00002284785,0.002029856,0.00006588253,0.00001707695,0.00007613575,0.00005983115,0.00003636321,0.9956983,0.00005727812,0.00005634081,0.001604168],"study_design_scores_gemma":[0.00004433794,0.0007999692,0.1331948,0.0000155933,0.000119901,0.002182335,0.0002864233,0.001075982,0.8543038,0.00009493832,0.00786329,0.00001865429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891367,0.00598652,0.001396222,0.00009126459,0.00003371863,0.00002540627,0.002035915,0.00004424038,0.00125004],"genre_scores_gemma":[0.9831639,0.00393161,0.002284814,0.00004644025,0.00003337847,0.00004905172,0.006954642,0.00001112711,0.003525103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003201547,"threshold_uncertainty_score":0.006365836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008087339792137457,"score_gpt":0.258556817897285,"score_spread":0.2504694781051475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}