{"id":"W1864382350","doi":"10.1158/1535-7163.641.3.5","title":"Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer","year":2004,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Pancreatic cancer; Identification (biology); Cancer; Polo-like kinase; Kinase; Biology; Cancer research; Computational biology; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001355115,0.0001964805,0.000217527,0.0002162374,0.0001066528,0.0003228675,0.0001122397,0.0002489312,0.0007753855],"category_scores_gemma":[0.0001473833,0.0001015985,0.0001079992,0.0001611682,0.0001992122,0.0002152486,0.0001073516,0.0004004902,0.0001804733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002632489,"about_ca_system_score_gemma":0.0001782524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001506803,"about_ca_topic_score_gemma":0.0003951333,"domain_scores_codex":[0.9999592,0.000008605231,0.000003750274,0.000009549372,0.000009091406,0.000009877263],"domain_scores_gemma":[0.999941,0.00001937302,0.00001659377,0.000004542234,0.000006834886,0.00001176179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004597464,0.00005828988,0.00282815,0.0001790643,0.0000113637,0.0002571843,0.00002723148,0.000333384,0.9732755,0.0003341275,0.0002327248,0.02200324],"study_design_scores_gemma":[0.00008189044,0.001361961,0.01382732,0.00002428617,0.00007014969,0.002351666,0.00005686034,0.001527234,0.9650949,0.0003563518,0.01523819,0.000009059013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606153,0.03211601,0.003293184,0.0008989524,0.00008195619,0.00004148283,0.0002089793,0.00006883064,0.002675111],"genre_scores_gemma":[0.9866218,0.009884911,0.001877922,0.0001208638,0.00003530747,0.00001911497,0.0003093473,0.000005769841,0.001124929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007753855,"threshold_uncertainty_score":0.002593935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01038560475883959,"score_gpt":0.2819086709854192,"score_spread":0.2715230662265796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}