{"id":"W1864437270","doi":"10.1523/jneurosci.20-22-08435.2000","title":"Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development","year":2000,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":352,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Medical Research Council; Medical Research Council Canada; National Institutes of Health; Rick Hansen Institute","keywords":"Dentate gyrus; Synaptogenesis; Neurogenesis; Hippocampal formation; Granule cell; Internal medicine; Transgene; Endocrinology; Biology; Neuroscience; Genetically modified mouse; Neuron; Synapse; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009678813,0.0002853429,0.0002048242,0.0002991996,0.00007093168,0.0002142523,0.0001334031,0.0001439964,0.0002850428],"category_scores_gemma":[0.0001053169,0.0001515904,0.0001671973,0.0001269181,0.0002665229,0.0001756665,0.0001589922,0.0003935884,0.00009748404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002358997,"about_ca_system_score_gemma":0.000211826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009317,"about_ca_topic_score_gemma":0.001579436,"domain_scores_codex":[0.9999089,0.00000618018,0.000009255562,0.00002210676,0.00003120474,0.00002220809],"domain_scores_gemma":[0.9998704,0.00001286913,0.00004979749,0.00000835146,0.00001494999,0.00004364528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009430621,0.0000108164,0.0006819451,0.00001617004,0.000002608152,0.00004822435,0.00001488254,0.00002207878,0.9980053,0.0000299141,0.000009980865,0.001063671],"study_design_scores_gemma":[0.00002989042,0.0006467494,0.05164667,0.00001524637,0.00004154182,0.0004207319,0.00009319851,0.0005696263,0.9451175,0.0001191463,0.001289405,0.00001021437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970726,0.0007745006,0.001332097,0.00002742642,0.00001004679,0.00000815651,0.0001402781,0.00006081302,0.0005740754],"genre_scores_gemma":[0.9960614,0.001009084,0.001766757,0.00001741334,0.00000582435,0.00001866699,0.0001739172,0.00001922482,0.0009276766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009317,"threshold_uncertainty_score":0.002006948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161585705764793,"score_gpt":0.250375299139498,"score_spread":0.22875944208185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}