{"id":"W1865788423","doi":"10.4049/jimmunol.1200583","title":"SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"TLR4; Cell biology; Proinflammatory cytokine; Scaffold protein; p38 mitogen-activated protein kinases; Kinase; Signal transduction; Ubiquitin; Innate immune system; IκB kinase; MAP kinase kinase kinase; NF-κB; Protein kinase A; Receptor; Chemistry; Biology; Inflammation; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001130222,0.0002273241,0.0001436131,0.0001377171,0.0002428399,0.0002087183,0.0001729128,0.0002423338,0.0007859606],"category_scores_gemma":[0.00006959288,0.00007798072,0.0001894302,0.0000991844,0.000179634,0.0002238859,0.0002232356,0.000302398,0.0003116808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429529,"about_ca_system_score_gemma":0.0001527775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526206,"about_ca_topic_score_gemma":0.0003845948,"domain_scores_codex":[0.9999493,0.000008259924,0.000002590717,0.00001166003,0.00001323992,0.00001492761],"domain_scores_gemma":[0.999944,0.000006903877,0.00001949802,0.000004680279,0.000007726432,0.00001718735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001819246,0.00002161788,0.001704236,0.00005254461,0.000007993477,0.0001604483,0.00001470843,0.000175937,0.9936388,0.000400093,0.00009405626,0.003547626],"study_design_scores_gemma":[0.00001733547,0.0001966986,0.01396759,0.00000717074,0.00001554338,0.0007608575,0.00005732804,0.002383509,0.9774718,0.0002485531,0.004866531,0.000007131757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925784,0.002328831,0.003701826,0.0001814287,0.0000277353,0.00001145369,0.0001655488,0.00004163585,0.0009631455],"genre_scores_gemma":[0.9961718,0.0005217801,0.002106202,0.00003094613,0.00001084411,0.000007972189,0.000271837,0.000003156021,0.0008755578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007859606,"threshold_uncertainty_score":0.00262928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009212690275549294,"score_gpt":0.2230433004157871,"score_spread":0.2138306101402378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}