{"id":"W1865788423","doi":"10.4049/jimmunol.1200583","title":"SASH1 Is a Scaffold Molecule in Endothelial TLR4 Signaling","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research","keywords":"TLR4; Cell biology; Proinflammatory cytokine; Scaffold protein; p38 mitogen-activated protein kinases; Kinase; Signal transduction; Ubiquitin; Innate immune system; IκB kinase; MAP kinase kinase kinase; NF-κB; Protein kinase A; Receptor; Chemistry; Biology; Inflammation; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005474782,0.000141568,0.0002193686,0.0001021162,0.00005440036,0.00001737201,0.0005133284,0.0001562407,0.0001789024],"category_scores_gemma":[0.0001079475,0.00009988817,0.0001176926,0.000099393,0.000134028,0.000007795787,0.0001198717,0.0002696147,0.00006356652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002354307,"about_ca_system_score_gemma":0.0001112534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009048861,"about_ca_topic_score_gemma":0.00001026726,"domain_scores_codex":[0.9987818,0.0002407167,0.0004386306,0.0001188329,0.0001279715,0.0002920225],"domain_scores_gemma":[0.9991558,0.00005275075,0.0002953391,0.0002958752,0.000160956,0.00003923146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494867,0.00004842742,0.0003130312,0.000003099522,0.00009952976,0.000009546914,0.000303476,0.0001021995,0.9969652,0.00003246907,0.001101017,0.0008725686],"study_design_scores_gemma":[0.0009894583,0.0005893451,0.0007702083,0.00003028886,0.00002332435,0.0004104581,0.0003023366,0.00002498217,0.9935067,0.0005261318,0.002704094,0.0001227052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945283,0.003320968,0.0006169242,0.0007804598,0.0002302643,0.0001187432,0.000003682572,0.000003889831,0.0003967821],"genre_scores_gemma":[0.9980078,0.0002955794,0.0004296244,0.0007607001,0.0002164281,0.000004431366,0.00000208965,0.00002237017,0.0002610043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003479486,"threshold_uncertainty_score":0.4073321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009212690275549294,"score_gpt":0.2230433004157871,"score_spread":0.2138306101402378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}