{"id":"W1865808828","doi":"10.1039/c5nr02377g","title":"Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids","year":2015,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Peptide; Intracellular; Colloidal gold; In vivo; Drug delivery; In vitro; Nanoparticle; Drug; Nanotechnology; Materials science; Chemistry; Pharmacology; Biochemistry; Medicine; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002376917,0.0001753305,0.0001969,0.00004590916,0.00003425331,0.00001934714,0.0001971105,0.00008528564,0.00001168873],"category_scores_gemma":[0.00006408177,0.0001493892,0.00008031535,0.0001104747,0.0001278659,0.00001374324,0.00007721304,0.00007337992,0.00003306858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002495275,"about_ca_system_score_gemma":0.0001990383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007468772,"about_ca_topic_score_gemma":0.0001229498,"domain_scores_codex":[0.9988686,0.0001021899,0.0002310004,0.0003307233,0.0002309706,0.0002364712],"domain_scores_gemma":[0.999066,0.00002189203,0.0001067455,0.000309299,0.0003612206,0.0001348543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006615573,0.0001205012,0.005223293,0.00001403723,0.00006305292,0.00001336658,0.0001576981,0.0003369719,0.9764803,0.00002795116,0.01607827,0.0008230101],"study_design_scores_gemma":[0.001072312,0.001175783,0.001814979,0.00003787235,0.00003925225,0.00002226664,0.0001684137,0.0001277767,0.9895746,0.00005817186,0.005700667,0.0002079284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996319,0.000681208,0.001336469,0.00008112368,0.00009530787,0.0003029653,0.00001763755,0.00001511232,0.001151172],"genre_scores_gemma":[0.9952758,0.00002533691,0.0009793489,0.0001965753,0.0001324766,0.00005348388,0.00006281665,0.00002237164,0.003251773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01309429,"threshold_uncertainty_score":0.6091915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008681572126109304,"score_gpt":0.2179410006941173,"score_spread":0.209259428568008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}