{"id":"W1865808828","doi":"10.1039/c5nr02377g","title":"Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids","year":2015,"lang":"en","type":"article","venue":"Nanoscale","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Peptide; Intracellular; Colloidal gold; In vivo; Drug delivery; In vitro; Nanoparticle; Drug; Nanotechnology; Materials science; Chemistry; Pharmacology; Biochemistry; Medicine; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002497194,0.0005084773,0.000421328,0.0001800872,0.0001895749,0.0003797268,0.0002944056,0.0004536962,0.0003549596],"category_scores_gemma":[0.000153528,0.0002293656,0.0002352663,0.0001062929,0.0002981591,0.000294071,0.0002186167,0.0004987274,0.0002780474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00067329,"about_ca_system_score_gemma":0.0003174422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004219746,"about_ca_topic_score_gemma":0.0007634287,"domain_scores_codex":[0.9998248,0.00002316331,0.00001729965,0.00005119868,0.00004968152,0.00003383136],"domain_scores_gemma":[0.9999247,0.0000158621,0.00002508128,0.000007581295,0.00001424813,0.00001259039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002961539,0.00002161475,0.00003251566,0.00003004092,0.000005783482,0.00004057352,0.00001157849,0.0006747562,0.9970825,0.0003001719,0.00004089755,0.001729871],"study_design_scores_gemma":[0.00001739008,0.0001048629,0.00009433136,0.000001448852,0.000009125787,0.00004713576,0.000003794411,0.002123005,0.9964473,0.00003460937,0.001110332,0.000006761941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9456981,0.001969088,0.04898636,0.0002904749,0.00009568492,0.0001818708,0.0001538522,0.0003329733,0.002291575],"genre_scores_gemma":[0.9763132,0.0005536836,0.02100426,0.00008853238,0.00001742229,0.00008689919,0.00009288188,0.0000412333,0.001801843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00067329,"threshold_uncertainty_score":0.004885137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008681572126109304,"score_gpt":0.2179410006941173,"score_spread":0.209259428568008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}