{"id":"W1869447046","doi":"10.1111/cmi.12279","title":"<scp><i>M</i></scp><i>ycobacterium leprae</i>intracellular survival relies on cholesterol accumulation in infected macrophages: a potential target for new drugs for leprosy treatment","year":2014,"lang":"en","type":"article","venue":"Cellular Microbiology","topic":"Leprosy Research and Treatment","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"CD36; Mycobacterium leprae; Biology; Intracellular; Chinese hamster ovary cell; Lipid metabolism; Glycolipid; Sterol regulatory element-binding protein; Cholesterol; Microbiology; In vitro; Receptor; Biochemistry; Sterol; Leprosy; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203732,0.0006664841,0.0008882229,0.0004877253,0.0004618067,0.000612933,0.0003605179,0.0007425143,0.01304356],"category_scores_gemma":[0.0003129006,0.0002353361,0.0003617997,0.0004780306,0.0004579952,0.0002551346,0.0004088269,0.001381961,0.005038386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000500619,"about_ca_system_score_gemma":0.0003840026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001694085,"about_ca_topic_score_gemma":0.002099576,"domain_scores_codex":[0.9995472,0.0001116693,0.00004778858,0.00006989871,0.0001290025,0.00009436988],"domain_scores_gemma":[0.9997689,0.0000453083,0.00005800726,0.00004819921,0.00003838568,0.0000411386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002989915,0.0000556149,0.0001399781,0.0002388777,0.00001334718,0.0002869018,0.00001742933,0.00007140618,0.9916426,0.0003875284,0.002392399,0.004454878],"study_design_scores_gemma":[0.00007617226,0.0003941433,0.005862101,0.00007487206,0.00002615756,0.001452284,0.00008983832,0.001156099,0.9389942,0.0003038664,0.05154853,0.0000216757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7897724,0.03627554,0.03673386,0.009251751,0.003347721,0.0008005234,0.03397416,0.004938883,0.08490508],"genre_scores_gemma":[0.9174179,0.005536384,0.02014611,0.001763404,0.0003841266,0.0006384742,0.01215325,0.0006540598,0.04130631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01304356,"threshold_uncertainty_score":0.04363501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02197725667103576,"score_gpt":0.2838768382435457,"score_spread":0.2618995815725099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}