{"id":"W1870122945","doi":"10.1038/leu.2015.264","title":"Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression","year":2015,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"","keywords":"Leukemia; Dynamics (music); Somatic evolution in cancer; Hematology; Myeloid leukemia; Oncology; Medicine; Biology; Cancer research; Internal medicine; Cancer; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348363,0.0002178852,0.0005331716,0.0001892188,0.00007175524,0.00002582841,0.0002941701,0.0002431757,0.00002542854],"category_scores_gemma":[0.0008326531,0.000160128,0.0001548411,0.0005301494,0.0007249696,0.0001071024,0.0001543906,0.000615947,0.00001869744],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008849016,"about_ca_system_score_gemma":0.002219593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008688552,"about_ca_topic_score_gemma":0.0009635399,"domain_scores_codex":[0.9977104,0.0001687488,0.0005879304,0.0003807097,0.0005944375,0.0005577606],"domain_scores_gemma":[0.9982601,0.0003137048,0.0002045626,0.0006167557,0.0003227367,0.0002821727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.03720716,0.003806763,0.156507,0.005560348,0.001229928,0.03430459,0.02873815,0.002047188,0.09837165,0.07084237,0.2309728,0.3304121],"study_design_scores_gemma":[0.08918624,0.01046455,0.1068564,0.003331498,0.0008518426,0.02660983,0.02208654,0.6381276,0.03247926,0.03905524,0.02834789,0.002603177],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943427,0.0001849964,0.0002731199,0.001428864,0.0001176272,0.001638316,0.0000947365,0.00005393498,0.001865634],"genre_scores_gemma":[0.9898109,0.00000837448,0.008552908,0.0002893312,0.0001999356,0.0001314002,0.0001474129,0.00005339524,0.0008062892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6360804,"threshold_uncertainty_score":0.9949558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09765468801876845,"score_gpt":0.3593394590796658,"score_spread":0.2616847710608974,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}