{"id":"W1871202334","doi":"10.1056/nejmsr1501341","title":"Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":937,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute; National Institute for Health and Care Research; Cancer Research UK","keywords":"Breast cancer; Cancer; Gene; Oncology; Genetics; Biology; Medicine; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009120199,0.00006568262,0.0001567712,0.00003869474,0.0000257795,0.000003409357,0.00009157621,0.00004583221,0.00001414018],"category_scores_gemma":[0.000255827,0.00003602925,0.00002942257,0.0000595091,0.0001865079,0.000004451826,0.00002123808,0.0001152994,1.501754e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003652993,"about_ca_system_score_gemma":0.0003566725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00018108,"about_ca_topic_score_gemma":0.00002628681,"domain_scores_codex":[0.9992891,0.00009766663,0.0002704628,0.00007418277,0.0001987159,0.00006987605],"domain_scores_gemma":[0.9991874,0.00003493778,0.0003022292,0.0001118336,0.0002668903,0.00009668228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.006204983,0.00004153299,0.08162127,0.00005422159,0.0009628672,0.00001862591,0.008959033,0.008362228,0.4347025,0.000120376,0.05844241,0.40051],"study_design_scores_gemma":[0.4088418,0.00604396,0.1304219,0.0009554768,0.002724051,0.0159999,0.007314821,0.003205942,0.2513246,0.01158906,0.1609615,0.0006169947],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982042,0.01046213,0.002745008,0.003766797,0.0006331768,0.00006684002,0.0000228544,0.000001636453,0.0002595661],"genre_scores_gemma":[0.9917713,0.003611698,0.0005283685,0.0001693004,0.003808199,0.000001367973,0.000003542449,0.000007217259,0.00009904301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4026369,"threshold_uncertainty_score":0.146923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02829547494275979,"score_gpt":0.2730003300718091,"score_spread":0.2447048551290493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}