{"id":"W1872035376","doi":"10.1055/s-0037-1613448","title":"Differential regulation of P-selectin expression by protein kinase A and protein kinase G in thrombin-stimulated human platelets","year":2003,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Antiplatelet Therapy and Cardiovascular Diseases","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec","keywords":"Forskolin; Protein kinase A; Platelet activation; Adenylyl cyclase; Platelet; cGMP-dependent protein kinase; Gs alpha subunit; Chemistry; Thrombin; Intracellular; P-selectin; cAMP-dependent pathway; Phosphodiesterase 3; Kinase; Endocrinology; Internal medicine; Signal transduction; Biology; Mitogen-activated protein kinase kinase; Biochemistry; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001023206,0.0001386429,0.0001695085,0.0002883476,0.0001240376,0.0003408055,0.00007028926,0.0002054623,0.001046606],"category_scores_gemma":[0.000172538,0.0001113294,0.0001784902,0.0001861599,0.0001196193,0.000156194,0.00009618879,0.0002505424,0.0003214035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679662,"about_ca_system_score_gemma":0.0001208472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003726,"about_ca_topic_score_gemma":0.00029973,"domain_scores_codex":[0.9998885,0.00003463744,0.000009469383,0.00001638583,0.00002100091,0.00003008957],"domain_scores_gemma":[0.9999481,0.00001621828,0.00001065501,0.000005285972,0.000005628874,0.00001414467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008016881,0.00002614956,0.0005529058,0.00003962751,0.000007610217,0.0002308982,0.00003845705,0.00004340542,0.9963612,0.0001607544,0.00006801438,0.00166936],"study_design_scores_gemma":[0.0001444471,0.001225803,0.09399328,0.00001635451,0.00006531557,0.002655077,0.0001787309,0.001911329,0.8958967,0.0004354707,0.003459706,0.00001767564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993843,0.00346107,0.0008628478,0.00009842793,0.0000215256,0.00002265907,0.0002606167,0.00001453569,0.001415348],"genre_scores_gemma":[0.9968479,0.001325813,0.0005097619,0.00003791018,0.00001605186,0.0000347969,0.0003119015,0.000004714794,0.0009112399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046606,"threshold_uncertainty_score":0.003501236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622724144254891,"score_gpt":0.2829478280812679,"score_spread":0.256720586638719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}