{"id":"W1872111533","doi":"10.4049/jimmunol.1002864","title":"A Single Nucleotide Polymorphism in NF-κB Inducing Kinase Is Associated with Mortality in Septic Shock","year":2011,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; St. Paul's Hospital; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Septic shock; Single-nucleotide polymorphism; Nucleotide; Polymorphism (computer science); Biology; NF-κB; Genetics; Microbiology; Sepsis; Immunology; Gene; Signal transduction; Allele; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006451107,0.0003972216,0.0003802412,0.0003018378,0.0002234485,0.0003411254,0.0002436193,0.0003943609,0.001027093],"category_scores_gemma":[0.001807307,0.0002005564,0.0004843686,0.0004621994,0.0002862465,0.0001376776,0.0003289149,0.0005884231,0.0001219452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001367354,"about_ca_system_score_gemma":0.000203331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000789837,"about_ca_topic_score_gemma":0.0008176044,"domain_scores_codex":[0.9996576,0.000114225,0.0000376216,0.0001069691,0.00004054503,0.00004302713],"domain_scores_gemma":[0.9983492,0.0004613,0.0006956133,0.000126984,0.00009540578,0.0002714089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00399589,0.0001067295,0.9823273,0.00004566808,0.0004025867,0.0002876841,0.00007929995,0.0002306133,0.009869928,0.00003157277,0.00009527191,0.00252745],"study_design_scores_gemma":[0.0001696847,0.0006598646,0.9972416,0.00000788796,0.0001742122,0.0003640435,0.00005460129,0.0005098706,0.000592443,0.0001121601,0.000104518,0.000009194815],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996089,0.0001126271,0.0001019406,0.00002272193,0.000004182586,0.000002441739,0.00008777542,0.000002043958,0.00005746092],"genre_scores_gemma":[0.9996588,0.00003502595,0.00008084974,0.00002046696,0.000008556631,0.000005244984,0.0001282919,0.000001218597,0.00006150947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027093,"threshold_uncertainty_score":0.003436029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03029307712949896,"score_gpt":0.2335123013650804,"score_spread":0.2032192242355814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}