{"id":"W1872184414","doi":"10.1111/nyas.12823","title":"Age‐related aspects of human IgM<sup>+</sup> B cell heterogeneity","year":2015,"lang":"en","type":"article","venue":"Annals of the New York Academy of Sciences","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Rosetrees Trust; King's College London; Medical Research Council; National Institute for Health and Care Research","keywords":"Immunoglobulin D; Immunology; Repertoire; Biology; Antibody; Immune system; Memory B cell; Population; Immunoglobulin M; Naive B cell; B cell; B-1 cell; Immunoglobulin G; T cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002095062,0.00008931357,0.0000939348,0.0004155128,0.000100546,0.0002318785,0.0001101912,0.0001635709,0.001943037],"category_scores_gemma":[0.0002822934,0.00009809519,0.00009713625,0.0002246341,0.0001082765,0.0001807166,0.0002024473,0.0001833608,0.0004210815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009680603,"about_ca_system_score_gemma":0.00005911765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005354007,"about_ca_topic_score_gemma":0.0003516737,"domain_scores_codex":[0.999898,0.00001995094,0.00001045589,0.00002861121,0.00002089374,0.00002212808],"domain_scores_gemma":[0.9998568,0.00003559738,0.00004441443,0.00001994605,0.00002250357,0.00002063541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008582919,0.00004753496,0.059855,0.00006442241,0.00004194325,0.000349404,0.0002530491,0.0001679216,0.9194915,0.0003911732,0.0003747689,0.01810492],"study_design_scores_gemma":[0.0000261475,0.0006634765,0.8631142,0.00001519989,0.00006842115,0.00380441,0.0002737418,0.0005849994,0.12144,0.0006130115,0.009379064,0.0000173123],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948477,0.002694298,0.0006867201,0.00005844593,0.000007608634,0.000007510315,0.000270168,0.000009786969,0.001417801],"genre_scores_gemma":[0.9982532,0.0005433598,0.0001685851,0.00003853904,0.00001911319,0.000008987789,0.0002974738,0.000004487131,0.0006663158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001943037,"threshold_uncertainty_score":0.006500185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08476061404709619,"score_gpt":0.3125170190121297,"score_spread":0.2277564049650335,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}