{"id":"W1872581706","doi":"10.1186/1472-6750-6-43","title":"The cumate gene-switch: a system for regulated expression in mammalian cells.","year":2006,"lang":"en","type":"article","venue":"BMC Biotechnology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Institut National de la Recherche Scientifique; BC Cancer Agency; AstraZeneca (Canada); Université de Montréal; National Research Council Canada","funders":"","keywords":"Transactivation; Biology; Repressor; Cell biology; Activator (genetics); Regulation of gene expression; Gene; Transcription (linguistics); Transcription factor; Promoter; Transgene; Psychological repression; Gene expression; Trans-acting; Mutant; Genetics; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006261133,0.0009154782,0.0005358012,0.0005732523,0.0003735182,0.0005503322,0.001072807,0.0005706224,0.003705224],"category_scores_gemma":[0.0002634176,0.0004156441,0.0006593664,0.0003915861,0.0004886513,0.0004328596,0.0007178016,0.001392222,0.002640186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006445235,"about_ca_system_score_gemma":0.0003945972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004580406,"about_ca_topic_score_gemma":0.0006946095,"domain_scores_codex":[0.999521,0.00009427907,0.00003415617,0.0001008019,0.0002031596,0.00004655674],"domain_scores_gemma":[0.9998131,0.00003770799,0.00004719005,0.00004131913,0.00001615237,0.00004443443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001003192,0.00002334295,0.00005773023,0.0000787051,0.00000991572,0.00004365606,0.00001666971,0.00005718464,0.9942203,0.0008007325,0.0005233147,0.004068178],"study_design_scores_gemma":[0.00005812219,0.0001864258,0.0006027213,0.00001330554,0.00003649835,0.0004732452,0.000007030979,0.0006828082,0.9471072,0.000189845,0.05062724,0.00001560383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.365993,0.01123435,0.5682951,0.001460214,0.001712661,0.002446338,0.0110776,0.01168199,0.02609863],"genre_scores_gemma":[0.5615873,0.0108678,0.3531509,0.0008569108,0.0003134935,0.002787842,0.02548059,0.002108895,0.04284628],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003705224,"threshold_uncertainty_score":0.01239526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009837087450273506,"score_gpt":0.248585893843759,"score_spread":0.2387488063934855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}