{"id":"W1872801834","doi":"10.3934/molsci.2015.4.382","title":"SUMO modulation of protein aggregation and degradation","year":2015,"lang":"en","type":"article","venue":"AIMS molecular science","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"SUMO protein; Protein aggregation; Neurodegeneration; Amyotrophic lateral sclerosis; Ubiquitin; Cell biology; Proteasome; Protein degradation; Biology; Intracellular; Neuroscience; Chemistry; Disease; Biochemistry; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003327095,0.0004412502,0.0003301304,0.0003067261,0.0002958397,0.0007860194,0.0001874867,0.0003357194,0.001530082],"category_scores_gemma":[0.0001986157,0.0001220065,0.0004505354,0.0002921055,0.0002246953,0.0004538787,0.0004539787,0.0003476421,0.000581126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004422737,"about_ca_system_score_gemma":0.0001853978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002699464,"about_ca_topic_score_gemma":0.0003436951,"domain_scores_codex":[0.9997851,0.00003676758,0.0000268754,0.00004364123,0.00005547939,0.0000523014],"domain_scores_gemma":[0.9999161,0.000008064054,0.00002393047,0.00001164513,0.00002671221,0.00001350776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006343979,0.0000768059,0.003052644,0.0009359909,0.0001480665,0.001084047,0.000186866,0.0006563508,0.9264032,0.007520328,0.002065403,0.05723591],"study_design_scores_gemma":[0.0000431081,0.0004072769,0.02308587,0.0001006141,0.0001067266,0.002130586,0.0001762852,0.001638774,0.890303,0.003551391,0.07842535,0.00003094026],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7418562,0.2121879,0.01299793,0.001651457,0.0007308165,0.0001165177,0.001429962,0.0004081569,0.02862107],"genre_scores_gemma":[0.9366257,0.05116518,0.002057065,0.0002476804,0.0001169823,0.00003856954,0.0005338347,0.00003074105,0.009184103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530082,"threshold_uncertainty_score":0.005118608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01848167440013597,"score_gpt":0.2540406847600346,"score_spread":0.2355590103598986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}