{"id":"W1873092316","doi":"10.1128/jvi.03631-14","title":"Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5′ Untranslated Region","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; Three prime untranslated region; Untranslated region; Genome; Genetics; microRNA; Virology; Viral replication; Virus; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002878821,0.0005489826,0.0002885112,0.0001147741,0.0001952486,0.000358184,0.0002830221,0.0003016252,0.001493228],"category_scores_gemma":[0.000211423,0.0002498523,0.0003347458,0.00008557632,0.0002901285,0.0002239235,0.0002680077,0.0002890106,0.0006090469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003809711,"about_ca_system_score_gemma":0.0001763428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005989924,"about_ca_topic_score_gemma":0.0007832976,"domain_scores_codex":[0.9997495,0.00006507093,0.00002731818,0.00007662434,0.00004190783,0.00003952353],"domain_scores_gemma":[0.9998233,0.00003547154,0.00006646963,0.00001919063,0.00002544745,0.00003011062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003251839,0.0000209457,0.0006524685,0.00006059909,0.000006807055,0.0000352087,0.00001562874,0.00005316096,0.9975784,0.00005888733,0.00003821139,0.001154624],"study_design_scores_gemma":[0.00003532643,0.0003033652,0.02037746,0.00001416319,0.0000223955,0.0002781678,0.00003608945,0.001934635,0.9749675,0.00003512678,0.001985806,0.00000985147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892589,0.005699288,0.002820259,0.0001235485,0.00003568338,0.00003131244,0.0002950037,0.00008406674,0.001652],"genre_scores_gemma":[0.9945814,0.0009094377,0.00252288,0.00004401675,0.000009805236,0.00003750975,0.000438766,0.00002122638,0.001434941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493228,"threshold_uncertainty_score":0.004995286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163634100504859,"score_gpt":0.2645234318018628,"score_spread":0.2428870907968142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}