{"id":"W1873092316","doi":"10.1128/jvi.03631-14","title":"Regulation of Hepatitis C Virus Genome Replication by Xrn1 and MicroRNA-122 Binding to Individual Sites in the 5′ Untranslated Region","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; Three prime untranslated region; Untranslated region; Genome; Genetics; microRNA; Virology; Viral replication; Virus; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006173301,0.0000786391,0.0001391113,0.0001243778,0.00002242758,0.00001119759,0.000152324,0.0001309439,0.000002357881],"category_scores_gemma":[0.0001241461,0.00006484489,0.00003643661,0.0001295976,0.00005585803,0.00001075501,0.00002957388,0.00007889089,9.486423e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002152541,"about_ca_system_score_gemma":0.00004436649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002919017,"about_ca_topic_score_gemma":0.00005208257,"domain_scores_codex":[0.9990755,0.000179398,0.0003668599,0.0001474527,0.0001240192,0.0001067467],"domain_scores_gemma":[0.99926,0.00001976318,0.0003422213,0.0002012077,0.0001176458,0.00005915437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002149545,0.00006625463,0.02146738,0.000006210098,0.00002827656,0.000002663434,0.0003692518,0.0001268061,0.9755349,0.00001238715,0.001541463,0.0006294171],"study_design_scores_gemma":[0.002090063,0.001260184,0.6241337,0.00002265743,0.00007424875,0.0004132326,0.0000795211,0.00009934015,0.3615249,0.0005161148,0.009622816,0.0001632015],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961193,0.001467555,0.001252115,0.0009464542,0.00003486695,0.0001432766,0.00001847171,0.000001476717,0.00001645591],"genre_scores_gemma":[0.9989305,0.0002047952,0.0004629027,0.0002065231,0.00007593774,0.000002970607,0.00009661711,0.000008669349,0.00001109788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.61401,"threshold_uncertainty_score":0.2644298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02163634100504859,"score_gpt":0.2645234318018628,"score_spread":0.2428870907968142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}