{"id":"W1873685494","doi":"10.1002/0471140856.tx1503s10","title":"Aggregation Chimeras (<scp>ES</scp> Cell–Embryo)","year":2001,"lang":"en","type":"article","venue":"Current Protocols in Toxicology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Chimera (genetics); Blastocyst; Embryo; Transgene; Biology; Genetically modified mouse; Cell biology; Andrology; Molecular biology; Genetics; Embryogenesis; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006906965,0.0006639957,0.00049486,0.0008216301,0.0006543635,0.0005854493,0.0008277005,0.0009278671,0.008513541],"category_scores_gemma":[0.0003196674,0.0004560782,0.0006861557,0.0004962942,0.0003699421,0.0004810688,0.001017741,0.002465126,0.004650195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003792499,"about_ca_system_score_gemma":0.0003678753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00123103,"about_ca_topic_score_gemma":0.002302647,"domain_scores_codex":[0.9995188,0.00005254049,0.00005153891,0.0001184459,0.0001902935,0.00006835927],"domain_scores_gemma":[0.9996104,0.00009184756,0.00009044835,0.00009230417,0.00003436108,0.0000807301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008521973,0.00003045763,0.000196264,0.00006210265,0.00002156254,0.0001781195,0.00003827398,0.0000889201,0.9903914,0.001196278,0.002205121,0.005506218],"study_design_scores_gemma":[0.00004801878,0.0001518068,0.003365497,0.00003235024,0.00007819859,0.002016264,0.00002726934,0.001428617,0.9047784,0.0005004695,0.08754999,0.00002319204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.4723139,0.008242949,0.4176194,0.002101603,0.001360192,0.001907404,0.01938821,0.01304707,0.0640192],"genre_scores_gemma":[0.6664424,0.008078447,0.1619636,0.001300809,0.0002123713,0.001636449,0.02660285,0.003872691,0.1298904],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.008513541,"threshold_uncertainty_score":0.02848065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0353437131801048,"score_gpt":0.3487922634216468,"score_spread":0.3134485502415419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}