{"id":"W1874766814","doi":"10.1080/15548627.2015.1034414","title":"Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia","year":2015,"lang":"en","type":"article","venue":"Autophagy","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"H2020 European Research Council; Canadian Institutes of Health Research","keywords":"Ceramide; Trophoblast; Autophagy; Biology; Sphingolipid; Sphingomyelin; Preeclampsia; Endocrinology; Oxidative stress; Internal medicine; Ceramide synthase; Cell biology; Placentation; Placenta; Biochemistry; Fetus; Medicine; Pregnancy; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005760936,0.0002505076,0.0003953474,0.0001520865,0.00003804572,0.00002512355,0.000325982,0.0002402558,0.0000236848],"category_scores_gemma":[0.0002363337,0.0002487814,0.0001329691,0.0002547853,0.00005780137,0.00002165074,0.0001677289,0.000149362,0.00001959187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003035589,"about_ca_system_score_gemma":0.0001765417,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003073926,"about_ca_topic_score_gemma":0.00004179798,"domain_scores_codex":[0.9981522,0.0001391947,0.0005203619,0.000466074,0.000315495,0.0004067037],"domain_scores_gemma":[0.998965,0.00001436947,0.0002030572,0.0005153443,0.0001225471,0.00017974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001407274,0.0001760548,0.001775103,0.00002926914,0.0000526439,0.000008319565,0.0005136736,0.0003828041,0.9916326,0.001068209,0.0002137053,0.004006892],"study_design_scores_gemma":[0.003251096,0.000169763,0.07405996,0.00003217368,0.00004871262,0.00001996761,0.0001764769,0.0007315347,0.9098585,0.0006947666,0.01058211,0.0003749806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948661,0.00193945,0.000530637,0.00003486196,0.0008999655,0.0002546766,0.00001220401,0.0000301197,0.001432007],"genre_scores_gemma":[0.9978389,0.00007691115,0.0008137521,0.0001657155,0.0005553248,0.00003428251,0.00007963208,0.00004024079,0.000395268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08177414,"threshold_uncertainty_score":0.9999964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932821587481086,"score_gpt":0.2836151531537934,"score_spread":0.2542869372789825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}