{"id":"W1876165947","doi":"10.4049/jimmunol.1303131","title":"A Humanized Antibody That Regulates the Alternative Pathway Convertase: Potential for Therapy of Renal Disease Associated with Nephritic Factors","year":2014,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Alexion Pharmaceuticals; GlaxoSmithKline","keywords":"C3-convertase; Alternative complement pathway; Complement system; Complement factor B; Chemistry; Factor H; Classical complement pathway; Glomerulonephritis; Immunology; Antibody; Cell biology; Medicine; Biology; Internal medicine; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009652236,0.0002241335,0.0005345457,0.000111814,0.0003198346,0.0000146443,0.00076428,0.00009272632,0.0002539957],"category_scores_gemma":[0.0003749981,0.0001051782,0.0002421771,0.00007459112,0.0007630355,0.00009295037,0.0000756749,0.0002755239,0.000004346717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003947169,"about_ca_system_score_gemma":0.0001253571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004397718,"about_ca_topic_score_gemma":0.0000148972,"domain_scores_codex":[0.9973634,0.001509441,0.0005611648,0.0001307343,0.0001046868,0.00033051],"domain_scores_gemma":[0.9961969,0.001776816,0.00122993,0.000380604,0.0003909183,0.00002484796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0142991,0.0006670449,0.01092039,0.00002652931,0.007081249,0.00001061248,0.002655888,0.000188603,0.9594943,0.002243106,0.001078232,0.001334919],"study_design_scores_gemma":[0.03244052,0.008227841,0.4786023,0.0009392942,0.001524167,0.0004070578,0.00496654,0.0002073336,0.4569442,0.007787763,0.007228626,0.0007242814],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901747,0.006877824,0.001187376,0.0005206345,0.0005777662,0.0005126097,0.0001210927,0.00001484062,0.00001322941],"genre_scores_gemma":[0.9993476,0.0002394937,0.000007007533,0.00009923039,0.00005131514,0.00001060097,0.00009310939,0.00002272086,0.0001288921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5025501,"threshold_uncertainty_score":0.4289041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01918320101337933,"score_gpt":0.2572778202158527,"score_spread":0.2380946192024733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}