{"id":"W1876272959","doi":"10.3109/10408444.2015.1074159","title":"Free radicals and related reactive species as mediators of tissue injury and disease: implications for Health","year":2015,"lang":"en","type":"review","venue":"Critical Reviews in Toxicology","topic":"Free Radicals and Antioxidants","field":"Chemistry","cited_by":336,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Radical; Free-radical theory of aging; Xenobiotic; Mechanism (biology); Antioxidant; Chemistry; Disease; Signal transduction; Detoxification (alternative medicine); Cell biology; Biochemistry; Biology; Medicine; Enzyme; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000998201,0.0003858533,0.003198916,0.000130576,0.0000696612,0.0000175128,0.0003645132,0.0005730879,0.0002431791],"category_scores_gemma":[0.01964134,0.0003115551,0.0002156541,0.0002032774,0.001151532,0.00005951858,0.0002159646,0.0005317182,0.000008522135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640584,"about_ca_system_score_gemma":0.0007609997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004711468,"about_ca_topic_score_gemma":0.000005195101,"domain_scores_codex":[0.9968135,0.0003302091,0.001615969,0.0006482172,0.0001315848,0.0004604615],"domain_scores_gemma":[0.995941,0.002065762,0.0004269161,0.0006263637,0.00007560007,0.0008642938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001328574,0.0001894088,0.00001336921,0.04876586,0.00003710508,0.000007617002,0.00002174335,2.013345e-9,0.00004319323,0.06833882,0.01479555,0.8677741],"study_design_scores_gemma":[0.0002504708,0.0001287297,0.00003834927,0.009948843,0.0003103142,0.00004962541,0.00000699643,6.998327e-7,0.000005531893,0.02967335,0.959343,0.0002441124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002555262,0.9915113,0.00001577362,0.004575914,0.0001229703,0.001011326,0.001711994,0.00002056613,0.001004543],"genre_scores_gemma":[0.00004643754,0.9981077,0.0004193253,0.0002846672,0.0001394922,0.0005865011,0.0001400738,0.00004498927,0.0002307548],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9445474,"threshold_uncertainty_score":0.9999337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06997286689688975,"score_gpt":0.4423321505451166,"score_spread":0.3723592836482268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}