{"id":"W1876395122","doi":"10.1093/glycob/cwv093","title":"Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes<i>N</i>-glycan phosphorylation in a branch-specific manner","year":2015,"lang":"en","type":"article","venue":"Glycobiology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Research Council Canada; School of Medicine, Emory University; U.S. Public Health Service; Health Research","keywords":"Mannose; Mannose 6-phosphate; Glycan; Chemistry; Mannose 6-phosphate receptor; Lysosome; Biochemistry; Mannosidase; Enzyme; Receptor; Glycoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007942958,0.0003052628,0.0002040047,0.000107273,0.00007945427,0.0001776563,0.0002801247,0.0003055475,0.001316931],"category_scores_gemma":[0.0001122277,0.0001172911,0.0002568778,0.0001003101,0.0001177775,0.0001289544,0.0001682892,0.0004836759,0.000525363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00022979,"about_ca_system_score_gemma":0.00009129154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004065396,"about_ca_topic_score_gemma":0.0004714972,"domain_scores_codex":[0.9999123,0.00001079199,0.000004699416,0.00002227105,0.00002801835,0.00002202466],"domain_scores_gemma":[0.9999181,0.00001759485,0.00002312768,0.00001115791,0.00001031457,0.00001962884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004027277,0.00001444885,0.0003617486,0.0000122278,0.000004740776,0.00002308649,0.000003745916,0.00004334232,0.9984849,0.00003074272,0.00002467448,0.0009561464],"study_design_scores_gemma":[0.00001066307,0.0002264701,0.01079454,0.00000324085,0.00001454797,0.0008559942,0.000009590935,0.001041592,0.984461,0.00003079652,0.002547575,0.000003988793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950575,0.0003815261,0.003151041,0.000044917,0.00001042464,0.00001790183,0.0002036564,0.00004004645,0.001092924],"genre_scores_gemma":[0.9947504,0.000208718,0.003203942,0.00005769611,0.00000531087,0.00001324825,0.000846052,0.00001178987,0.0009028336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001316931,"threshold_uncertainty_score":0.004405558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0458265511191107,"score_gpt":0.289993209338838,"score_spread":0.2441666582197273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}