{"id":"W1876729604","doi":"10.1139/bcb-2015-0018","title":"ClC-3 chloride channel functions as a mechanically sensitive channel in osteoblasts","year":2015,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fourth Military Medical University; Johns Hopkins University; National Science Foundation","keywords":"RUNX2; Alkaline phosphatase; Stimulation; Chloride channel; Signal transduction; Osteocalcin; Cell biology; Bone sialoprotein; Chemistry; Wnt signaling pathway; Osteoblast; Transforming growth factor; Transcription factor; Bone morphogenetic protein 2; Endocrinology; Biochemistry; Biology; Enzyme; In vitro; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002635791,0.0003466448,0.0004132349,0.0003425128,0.0005012801,0.0005842477,0.0004577405,0.0009679653,0.0008646568],"category_scores_gemma":[0.0003788829,0.0001804647,0.0005609738,0.0002865594,0.0006784241,0.0006049547,0.0004113567,0.0005984053,0.0002572818],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000799568,"about_ca_system_score_gemma":0.0008484971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002025038,"about_ca_topic_score_gemma":0.002327398,"domain_scores_codex":[0.9995608,0.00004161526,0.00003250871,0.000069708,0.0001903153,0.0001051173],"domain_scores_gemma":[0.9997643,0.00002833935,0.00007109518,0.00002347318,0.0000675654,0.00004515694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001345651,0.00002055005,0.0006885806,0.00009543315,0.000005758594,0.0002064766,0.0000302383,0.0001364451,0.9972034,0.0003050112,0.0001105663,0.001063067],"study_design_scores_gemma":[0.00008720664,0.0002390083,0.01321624,0.00002734791,0.0000551119,0.001047484,0.000184769,0.003955229,0.9755838,0.0006786973,0.004891505,0.00003357764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737166,0.007476081,0.01311456,0.00114646,0.0001744505,0.00008791611,0.0007034781,0.0003400166,0.003240504],"genre_scores_gemma":[0.9953129,0.001179906,0.001638811,0.000324108,0.00002458643,0.00004394309,0.0002688808,0.00002817448,0.001178627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002025038,"threshold_uncertainty_score":0.00580126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049933851489573,"score_gpt":0.2281134330652941,"score_spread":0.2176140945503983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}