{"id":"W1877580702","doi":"10.1093/molehr/gav058","title":"Induction of interferon-λ contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells","year":2015,"lang":"en","type":"article","venue":"Molecular Human Reproduction","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Fundamental Research Funds for the Central Universities; State Key Laboratory of Virology; Chinese Academy of Sciences; China Postdoctoral Science Foundation; Hubei Key Laboratory of Wudang Local Chinese Medicine Research; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China; McGill University","keywords":"IRF3; Biology; TLR3; Interferon; Herpes simplex virus; Western blot; IRF7; Virology; RIG-I; Viral replication; Transfection; Cell culture; Molecular biology; Innate immune system; Virus; Receptor; Toll-like receptor; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375562,0.0001330774,0.0002846348,0.0003848475,0.00005485184,0.00001049849,0.00003025271,0.0001302278,0.00001971246],"category_scores_gemma":[0.0002938273,0.0001335932,0.00004082704,0.0005234459,0.00008185755,0.00009920623,0.00003547196,0.0001148867,0.0000072116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193058,"about_ca_system_score_gemma":0.0000471287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066734,"about_ca_topic_score_gemma":0.00008211484,"domain_scores_codex":[0.998615,0.0001005352,0.0004732087,0.0004912371,0.0001927766,0.0001272832],"domain_scores_gemma":[0.9987569,0.0000138747,0.0001911465,0.0005305079,0.0004275646,0.00008003103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002893906,0.0005617687,0.001302278,0.00005160293,0.00006034104,0.000002956067,0.0003128549,0.00008605527,0.9829399,0.0004253686,0.00008615843,0.01388132],"study_design_scores_gemma":[0.001581857,0.0007747252,0.02169227,0.00009863975,0.00006138218,0.000007197747,0.0001137006,0.00002337577,0.9716184,0.001203896,0.002730495,0.00009406791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978384,0.00005084138,0.000713405,0.0003482432,0.0001262149,0.0006877212,0.000009249028,0.00003980157,0.0001860908],"genre_scores_gemma":[0.9994075,0.000008672047,0.0001547772,0.00004533004,0.00008198892,0.00003682985,0.0001887707,0.00002080046,0.00005528773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02038999,"threshold_uncertainty_score":0.5447772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03222705722359435,"score_gpt":0.3171392838671978,"score_spread":0.2849122266436034,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}