{"id":"W1878777740","doi":"10.1073/pnas.1504276112","title":"The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Autoimmunity; Inflammation; Immune system; Cytokine; Immunology; Biology; Immune tolerance; Cell biology; Myeloid; Immunity; Effector; Acquired immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002665767,0.00009942316,0.0001648184,0.0001026259,0.0005631049,0.00004421833,0.000486282,0.0001026164,0.000001318678],"category_scores_gemma":[0.0009981066,0.00005867516,0.00003776795,0.000318302,0.0009156368,0.0003556913,0.0002268763,0.0001885099,0.000003528493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004144448,"about_ca_system_score_gemma":0.00005354488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003418092,"about_ca_topic_score_gemma":4.833661e-8,"domain_scores_codex":[0.9989535,0.00006160459,0.0003811388,0.0001813072,0.0002367182,0.0001856923],"domain_scores_gemma":[0.9989807,0.0002378902,0.0004335988,0.00001603266,0.0003117206,0.00002005594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005685772,0.00001296709,0.002606802,0.00004407897,0.00001223005,2.143042e-9,0.00111397,0.00003324015,0.9941442,0.0009111026,0.0001873421,0.0008772123],"study_design_scores_gemma":[0.000217502,0.00005060973,0.05464868,0.0002716437,0.000009130345,0.00003544052,0.0005989548,0.0001590487,0.9427366,0.0008254911,0.0003786453,0.00006831788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958367,0.002197081,6.640636e-7,0.001276852,0.00006671416,0.0003117953,0.000006149642,0.00001444976,0.0002895362],"genre_scores_gemma":[0.9994463,0.00002578757,0.0001444956,0.00006860685,0.00002247498,0.0000137576,1.467503e-7,0.000003868377,0.0002745179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05204187,"threshold_uncertainty_score":0.4331004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040626055075303,"score_gpt":0.2848256109908398,"score_spread":0.2441995559155367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}