{"id":"W1878777740","doi":"10.1073/pnas.1504276112","title":"The amino acid sensor GCN2 inhibits inflammatory responses to apoptotic cells promoting tolerance and suppressing systemic autoimmunity","year":2015,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":163,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Autoimmunity; Inflammation; Immune system; Cytokine; Immunology; Biology; Immune tolerance; Cell biology; Myeloid; Immunity; Effector; Acquired immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008777863,0.0003697983,0.0002908366,0.0001341321,0.00008886237,0.0001768434,0.000156905,0.0002565963,0.0007918419],"category_scores_gemma":[0.00007483631,0.00009357584,0.0001532134,0.0000803045,0.0001629289,0.0001681899,0.0001731975,0.0004793011,0.000210321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002434605,"about_ca_system_score_gemma":0.0002100841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003438785,"about_ca_topic_score_gemma":0.0007241523,"domain_scores_codex":[0.9999064,0.00001797537,0.000006214764,0.00001730682,0.00002772903,0.00002426431],"domain_scores_gemma":[0.9999572,0.000003937148,0.00001090646,0.000004993209,0.0000052771,0.0000178105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001611531,0.00002008561,0.00005567708,0.00002024257,0.000002388546,0.00001467705,0.000003270679,0.0000428859,0.9989795,0.00003227771,0.00002407981,0.0006438114],"study_design_scores_gemma":[0.00003775106,0.0004374509,0.001393742,0.000004191734,0.000008204654,0.0001662891,0.000009448219,0.0007019108,0.9947655,0.00002829309,0.00244331,0.000003907931],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945465,0.001656687,0.001759904,0.0001334115,0.0000446552,0.00002704271,0.0002172552,0.00008458204,0.001529859],"genre_scores_gemma":[0.9947036,0.0007966014,0.002111278,0.00008542874,0.00001454542,0.0000374176,0.0003448116,0.00001608772,0.001890115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007918419,"threshold_uncertainty_score":0.002649009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040626055075303,"score_gpt":0.2848256109908398,"score_spread":0.2441995559155367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}