{"id":"W1879765960","doi":"10.1002/bdrb.21149","title":"Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs","year":2015,"lang":"en","type":"article","venue":"Birth Defects Research Part B Developmental and Reproductive Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Apoptosis; Biology; Histone deacetylase; Survivin; Poly ADP ribose polymerase; PARP1; Molecular biology; Cancer research; Caspase 3; DNA damage; Histone deacetylase inhibitor; Programmed cell death; Cell biology; Histone; Gene; Polymerase; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002094231,0.0001637042,0.0002960468,0.0002093486,0.0001401771,0.000007869668,0.0002597029,0.0001751668,0.0000125958],"category_scores_gemma":[0.001240348,0.0001042875,0.00004679238,0.0005529889,0.001150024,0.0000150132,0.0008164092,0.0002577006,0.000001540598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007263743,"about_ca_system_score_gemma":0.000539689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007035463,"about_ca_topic_score_gemma":0.0000971472,"domain_scores_codex":[0.997242,0.0009242279,0.0004172722,0.0005839095,0.0004760819,0.0003565215],"domain_scores_gemma":[0.9988084,0.0001081878,0.0001643325,0.0003974497,0.0004168816,0.0001047877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000561064,0.0002782642,0.01932347,0.0001301095,0.00004429391,0.00000280571,0.0006791185,0.00001530584,0.9760171,0.0000137443,0.0002787346,0.002655992],"study_design_scores_gemma":[0.0006744476,0.0007838184,0.03841572,0.00005681984,0.000004180502,0.00003746974,0.001062703,0.000003049026,0.9568654,0.00006137036,0.001928292,0.0001067346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935263,0.005057889,0.000003418035,0.0002908543,0.0001139123,0.0008107345,0.00001764173,0.000003346766,0.0001758485],"genre_scores_gemma":[0.9983484,0.000588784,0.0004996951,0.0000121193,0.00008719869,0.00007969001,0.00001700592,0.00001897635,0.0003481227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0191517,"threshold_uncertainty_score":0.4252721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04076084298877757,"score_gpt":0.2919301816735382,"score_spread":0.2511693386847606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}