{"id":"W1879765960","doi":"10.1002/bdrb.21149","title":"Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs","year":2015,"lang":"en","type":"article","venue":"Birth Defects Research Part B Developmental and Reproductive Toxicology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Apoptosis; Biology; Histone deacetylase; Survivin; Poly ADP ribose polymerase; PARP1; Molecular biology; Cancer research; Caspase 3; DNA damage; Histone deacetylase inhibitor; Programmed cell death; Cell biology; Histone; Gene; Polymerase; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009124168,0.0003309153,0.0002037523,0.0003816472,0.000112697,0.0002107627,0.0001150677,0.0001972123,0.0008687513],"category_scores_gemma":[0.00008043725,0.000215354,0.0002141957,0.0001149943,0.0002094293,0.0001253569,0.0001458382,0.000530619,0.0001874228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002769553,"about_ca_system_score_gemma":0.0001609419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005184072,"about_ca_topic_score_gemma":0.001001504,"domain_scores_codex":[0.9998628,0.00002398023,0.00001405558,0.00003375922,0.00003048333,0.00003487103],"domain_scores_gemma":[0.9998651,0.00001628056,0.00005194205,0.00001332131,0.0000106832,0.0000425794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001367638,0.00001305967,0.0001982328,0.00001588912,0.000003499366,0.00006118088,0.000009301941,0.0000284249,0.9990178,0.00002926021,0.00001491985,0.0004716472],"study_design_scores_gemma":[0.00001137512,0.0005086909,0.008872692,0.000006411491,0.00001328425,0.0002479502,0.00002421047,0.0002697844,0.9889397,0.00003822338,0.001065346,0.000002375428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943302,0.002646928,0.001329146,0.00006820205,0.000021576,0.00001818927,0.0004603074,0.00006274966,0.001062679],"genre_scores_gemma":[0.993843,0.001457799,0.0009934882,0.00005082233,0.000007792904,0.0000340045,0.0005636606,0.00001649821,0.003032922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008687513,"threshold_uncertainty_score":0.002906203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04076084298877757,"score_gpt":0.2919301816735382,"score_spread":0.2511693386847606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}