{"id":"W1880802948","doi":"10.1016/j.jacc.2015.05.046","title":"Clinical Trial Design Principles and Endpoint Definitions for Transcatheter Mitral Valve Repair and Replacement: Part 1: Clinical Trial Design Principles","year":2015,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":232,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital du Sacré-Cœur de Montréal","funders":"National Heart, Lung, and Blood Institute; Abbott Vascular; Boston Scientific Corporation; Edwards Lifesciences; Celgene; St. Jude Medical; European Commission; Celladon Corporation; Pfizer; Amgen","keywords":"Medicine; Mitral regurgitation; Clinical trial; Clinical endpoint; Mitral valve; Heart failure; Intensive care medicine; Cardiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.5920482,0.007266055,0.01687447,0.006968496,0.003824149,0.01424473,0.009389906,0.02228772,0.0052554],"category_scores_gemma":[0.5500614,0.008057988,0.01255839,0.004836746,0.01108384,0.006412772,0.005444992,0.03285618,0.005581688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005053881,"about_ca_system_score_gemma":0.01725798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000696856,"about_ca_topic_score_gemma":0.001055364,"domain_scores_codex":[0.3050167,0.5887942,0.06552863,0.009549893,0.02900151,0.002109094],"domain_scores_gemma":[0.3475416,0.5395138,0.03353246,0.03485466,0.04018527,0.004372316],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.02630741,0.001986378,0.00604991,0.05276525,0.01272586,0.0006763011,0.005151057,0.01251709,0.004548786,0.3743065,0.1737029,0.3292626],"study_design_scores_gemma":[0.06185313,0.008676554,0.007899623,0.04148531,0.01325063,0.002805843,0.0004736506,0.03370967,0.007457818,0.3998247,0.421261,0.001302158],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.002416015,0.03157466,0.8231059,0.03307472,0.007495775,0.08983984,0.003032722,0.001550213,0.007910037],"genre_scores_gemma":[0.01922922,0.005372471,0.728179,0.0241656,0.003819271,0.2161244,0.0009992985,0.0004496528,0.001661074],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.4079518,"threshold_uncertainty_score":0.5030772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2729149275853776,"score_gpt":0.427706379923543,"score_spread":0.1547914523381654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}