{"id":"W1880868311","doi":"10.1080/15548627.2015.1009794","title":"USP8 and PARK2/parkin-mediated mitophagy","year":2015,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Mitophagy; Parkin; Ubiquitin; Deubiquitinating enzyme; Biology; Ubiquitin ligase; PINK1; Cell biology; Mitochondrion; Autophagy; Ubiquitin-Protein Ligases; Ubiquitin-conjugating enzyme; Biochemistry; Parkinson's disease; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003015274,0.0002452813,0.0002055385,0.0001696134,0.0001718548,0.0003599566,0.0001642802,0.0003281742,0.0009542534],"category_scores_gemma":[0.0001496709,0.0001266699,0.000215303,0.00008399652,0.0002884018,0.0003194681,0.0003933166,0.0002522858,0.0001813154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003136849,"about_ca_system_score_gemma":0.0001276247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002085088,"about_ca_topic_score_gemma":0.0002919821,"domain_scores_codex":[0.9998449,0.00004726586,0.00001455999,0.00002400007,0.00003275816,0.00003650156],"domain_scores_gemma":[0.9999317,0.00001159819,0.00002271107,0.000008688984,0.000005402919,0.00001992572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001009483,0.00007012142,0.001834885,0.0001891816,0.00002484165,0.0009559075,0.00009489471,0.0003219386,0.9830728,0.003587603,0.0002368065,0.008601539],"study_design_scores_gemma":[0.00009996461,0.0005590143,0.02515885,0.00002837835,0.00003322591,0.004236823,0.0001297309,0.003165621,0.9489216,0.001335846,0.01631413,0.00001676499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803203,0.01415029,0.002017464,0.0002605759,0.00003697352,0.00001673494,0.00009302441,0.00003303106,0.003071632],"genre_scores_gemma":[0.9954304,0.001905787,0.0007457514,0.00004010732,0.00001425563,0.00001017348,0.00008860364,0.000004492687,0.001760536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009542534,"threshold_uncertainty_score":0.003192246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03420614248880946,"score_gpt":0.2886155742192049,"score_spread":0.2544094317303954,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}