{"id":"W1881181132","doi":"10.1038/srep00237","title":"Functional analysis of missense variants in the TRESK (KCNK18) K+ channel","year":2012,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Migraine and Headache Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Wellcome Trust; Pfizer","keywords":"Migraine; Familial hemiplegic migraine; Migraine with aura; Aura; Missense mutation; Photophobia; Medicine; Phonophobia; Cortical spreading depression; Genetics; Internal medicine; Mutation; Gene; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000264192,0.0003402611,0.0002791524,0.0006072214,0.0002105134,0.0002186534,0.0002197002,0.0005486236,0.001441142],"category_scores_gemma":[0.001153705,0.0001176315,0.0002856374,0.0003285313,0.0003283691,0.0001067124,0.0002003679,0.0002178001,0.0002772189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244178,"about_ca_system_score_gemma":0.0001142309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007041693,"about_ca_topic_score_gemma":0.0005748834,"domain_scores_codex":[0.9997479,0.00005510237,0.00004816365,0.00006196987,0.00005562068,0.00003124259],"domain_scores_gemma":[0.9992718,0.0003582993,0.000165663,0.00005344616,0.00006466998,0.00008610588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003356358,0.0004703033,0.1410432,0.0002563551,0.0002938251,0.05310268,0.001133166,0.0004853953,0.7791757,0.0004113815,0.0005031789,0.01976843],"study_design_scores_gemma":[0.0003745845,0.003316672,0.6434278,0.00006239503,0.0004753811,0.1788414,0.0005548891,0.001663061,0.1671937,0.0003231264,0.003694108,0.00007300849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990909,0.0001909991,0.0002101267,0.00002763361,0.0000123512,0.000009539788,0.00023659,0.000009090514,0.0002127018],"genre_scores_gemma":[0.999103,0.0001355438,0.0003293496,0.00003136745,0.00001448464,0.000006179299,0.0002160877,0.00000793954,0.0001560158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441142,"threshold_uncertainty_score":0.004821122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05173207650284085,"score_gpt":0.3015653444986107,"score_spread":0.2498332679957699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}