{"id":"W1881862380","doi":"10.1177/135965350501002s02","title":"Possible Ways Nucleoside Analogues Can Affect Mitochondrial Dna Content and Gene Expression during HIV Therapy","year":2005,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia","funders":"","keywords":"Mitochondrial toxicity; Nucleoside Reverse Transcriptase Inhibitor; Reverse transcriptase; Mitochondrial DNA; Toxicity; Biology; Nucleoside analogue; Mitochondrion; Reverse-transcriptase inhibitor; Nucleoside; Mitochondrial respiratory chain; Virology; Affect (linguistics); Pharmacology; Gene; Human immunodeficiency virus (HIV); Polymerase chain reaction; Medicine; Genetics; Internal medicine; Psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008882336,0.000313716,0.0004209848,0.0001425089,0.0002191049,0.00005288687,0.0000843391,0.0001020638,0.00008326428],"category_scores_gemma":[0.000007700563,0.0002161122,0.0001349857,0.0001271763,0.00007993892,0.0001672053,0.00002998341,0.0001360548,0.00004817104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007084923,"about_ca_system_score_gemma":0.00005052639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003042898,"about_ca_topic_score_gemma":0.00003183357,"domain_scores_codex":[0.9985974,0.00006191484,0.0002642484,0.0004156482,0.0002697806,0.0003909741],"domain_scores_gemma":[0.9994274,0.00004195486,0.00008526051,0.0002669189,0.00004482658,0.0001335806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001226631,0.000336877,0.0810407,0.000009562666,0.0001982275,0.00007725589,0.001547451,5.173254e-7,0.8929082,0.00002243484,0.001188701,0.02144342],"study_design_scores_gemma":[0.009178155,0.0002778288,0.1087059,0.0001136911,0.00002123148,0.00003049582,0.0001028068,0.0000189995,0.8764383,0.00002744765,0.004839365,0.0002457385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933686,0.002287129,0.00004107505,0.002700412,0.0001367318,0.0006981234,0.00001457239,0.0001275672,0.0006258498],"genre_scores_gemma":[0.9852581,0.005891414,0.002850097,0.0003475291,0.0005550077,0.0000469915,0.0000759214,0.00004669864,0.004928251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02766524,"threshold_uncertainty_score":0.8812802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03792874157312286,"score_gpt":0.2623311100440043,"score_spread":0.2244023684708814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}