{"id":"W1881989874","doi":"10.1161/circulationaha.115.018016","title":"Potassium Channel Blockade Enhances Atrial Fibrillation–Selective Antiarrhythmic Effects of Optimized State-Dependent Sodium Channel Blockade","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Dofetilide; Medicine; Potassium channel blocker; Blockade; Sodium channel blocker; Cardiology; Channel blocker; Atrial fibrillation; Internal medicine; Potassium channel; Sodium channel; Atrium (architecture); Electrophysiology; Antiarrhythmic agent; Pharmacology; Anesthesia; Sodium; Chemistry; Heart disease; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435025,0.0002560777,0.000310413,0.0001012812,0.00006330564,0.0003001719,0.0002104636,0.0001418323,0.0006186011],"category_scores_gemma":[0.0001797937,0.00008735052,0.0002950629,0.00006303949,0.000136483,0.0002466835,0.0001691596,0.0002958581,0.0001344922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060819,"about_ca_system_score_gemma":0.0002046401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001899938,"about_ca_topic_score_gemma":0.0003300473,"domain_scores_codex":[0.9999262,0.00001183194,0.00001042517,0.00001431412,0.00001919365,0.00001813225],"domain_scores_gemma":[0.9999169,0.00001909372,0.00003278311,0.000008503677,0.000009122192,0.00001356623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002710204,0.00009955575,0.0005540763,0.00009499866,0.00003231717,0.00002853321,0.00001448458,0.001070383,0.9947681,0.000346043,0.00003659714,0.002683906],"study_design_scores_gemma":[0.0001354482,0.002784634,0.006647869,0.00002393242,0.0002033295,0.0003687483,0.00002422206,0.02510911,0.9617671,0.0003221582,0.00259504,0.00001842935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915906,0.00105189,0.006183555,0.00003761704,0.0000137042,0.00001392269,0.00005668786,0.00007619525,0.0009758555],"genre_scores_gemma":[0.9971491,0.0005760275,0.001957832,0.0000196275,0.000005926609,0.00001181304,0.00007488176,0.0000089473,0.0001959098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006186011,"threshold_uncertainty_score":0.002069473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03249004401395542,"score_gpt":0.293310504623475,"score_spread":0.2608204606095196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}