{"id":"W1882026650","doi":"10.1074/jbc.m115.679050","title":"Sph3 Is a Glycoside Hydrolase Required for the Biosynthesis of Galactosaminogalactan in Aspergillus fumigatus","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Aspergillus fumigatus; Glycoside hydrolase; Virulence; Hydrolase; Biology; Gene cluster; Biochemistry; Microbiology; Mutagenesis; Gene; Mutant; Aspergillus; Fungal protein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004199829,0.000385985,0.0001464112,0.0001655593,0.0001603171,0.0001711265,0.00009749128,0.0001437522,0.0005813327],"category_scores_gemma":[0.00007841164,0.00009538972,0.0002549148,0.000184268,0.0001323552,0.00009154435,0.0001414751,0.000237779,0.0003784362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003968526,"about_ca_system_score_gemma":0.0003146551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005035485,"about_ca_topic_score_gemma":0.003254146,"domain_scores_codex":[0.9999667,0.000003421511,0.000002686525,0.000006667304,0.00001393675,0.000006434997],"domain_scores_gemma":[0.9999522,0.000004948099,0.00001231019,0.000003251932,0.000005292258,0.00002210165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001104214,0.00001145785,0.001284835,0.00002233974,0.000003978877,0.0001861717,0.00001611833,0.0001385256,0.9966196,0.00008437365,0.00006026785,0.001462086],"study_design_scores_gemma":[0.00003182317,0.0002686048,0.08216271,0.00001695262,0.00002679226,0.00184535,0.0001335428,0.003214311,0.9051249,0.00037196,0.00678796,0.00001503524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953442,0.0006475265,0.002068246,0.00008047192,0.00002024576,0.00001145695,0.0007113837,0.0001104938,0.001005958],"genre_scores_gemma":[0.9938459,0.0002881385,0.002107454,0.00003545731,0.000004826692,0.000005675388,0.002343624,0.00001712192,0.00135167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005035485,"threshold_uncertainty_score":0.01001239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03965432157623142,"score_gpt":0.2682614369875269,"score_spread":0.2286071154112955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}