{"id":"W1882732891","doi":"10.1016/j.envres.2015.10.020","title":"Chronic exposure to hexachlorobenzene results in down-regulation of connexin43 in the breast","year":2015,"lang":"en","type":"article","venue":"Environmental Research","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Universitaire Stichting; Canadian Liver Foundation; Armand-Frappier Foundation","keywords":"Protein kinase B; Hexachlorobenzene; PI3K/AKT/mTOR pathway; Breast cancer; In vitro; Chemistry; Endocrinology; SKBR3; Internal medicine; Cancer research; Biology; Signal transduction; Medicine; Cancer; Biochemistry; Human breast","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131477,0.0001697673,0.0002759989,0.0003173999,0.0003946614,0.0004009693,0.0001215123,0.0002280977,0.002438952],"category_scores_gemma":[0.0001794693,0.000276724,0.0003149621,0.0003641491,0.0002180206,0.000191592,0.0001880035,0.000282657,0.0003431936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000637811,"about_ca_system_score_gemma":0.0004237785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007497455,"about_ca_topic_score_gemma":0.01226489,"domain_scores_codex":[0.9998106,0.00002403308,0.00001325464,0.00003956237,0.0000465618,0.00006601384],"domain_scores_gemma":[0.9998265,0.0000313607,0.00004113042,0.0000262682,0.00003246001,0.00004234068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004361313,0.00003156891,0.002291696,0.00002178206,0.00001529513,0.00009677467,0.00003379313,0.00002516231,0.9962751,0.00003756123,0.00006244394,0.0006727954],"study_design_scores_gemma":[0.00001612669,0.0004110738,0.1244694,0.000007824219,0.00006174778,0.0007353487,0.0004107646,0.0001980738,0.8717822,0.00006791499,0.00182944,0.00001007928],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976078,0.0009575225,0.0003740274,0.00007662751,0.0000164142,0.0000045366,0.0003315469,0.00001463497,0.000616862],"genre_scores_gemma":[0.995684,0.0008866803,0.0002052423,0.00003177368,0.000005034731,0.000009613374,0.0003705251,0.000009693486,0.002797408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007497455,"threshold_uncertainty_score":0.01490766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03526955610481054,"score_gpt":0.3121944809468624,"score_spread":0.2769249248420519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}