{"id":"W1883167815","doi":"10.4049/jimmunol.0901409","title":"Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Commonwealth Foundation","keywords":"clone (Java method); Epitope; Affinity maturation; Polyclonal antibodies; Ganglioside; Biology; Molecular biology; Antibody; Immunohistochemistry; In vitro; Monoclonal antibody; Epitope mapping; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003235778,0.00008941149,0.0002925741,0.000187674,0.00008111438,0.000007580843,0.0001562956,0.00005225472,0.00002923621],"category_scores_gemma":[0.0001634646,0.00005441294,0.00007234349,0.0001470408,0.0000874697,0.0001789374,0.00002552735,0.0003556512,0.000006570268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003991455,"about_ca_system_score_gemma":0.00008351268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002830295,"about_ca_topic_score_gemma":0.000002053003,"domain_scores_codex":[0.9989747,0.0002130572,0.0003509331,0.00006852016,0.0001923028,0.000200441],"domain_scores_gemma":[0.9991565,0.00007485643,0.000309057,0.0002517728,0.0001481897,0.00005966588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002342221,0.0003253976,0.0004333252,0.00001180557,0.0001484455,0.0003484592,0.0002579524,0.00002126319,0.992151,0.00001905745,0.00001594256,0.003925086],"study_design_scores_gemma":[0.001470233,0.002450796,0.4024012,0.0001091822,0.00007277074,0.004004783,0.0001134331,0.00001194258,0.5891995,0.0001277355,0.000007341621,0.00003109623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997526,0.0008170732,0.00001493446,0.001195458,0.0001230823,0.0001142754,0.000001330357,0.000009167489,0.0001986831],"genre_scores_gemma":[0.998907,0.0006285033,0.0002528673,0.00004881573,0.0001066844,2.065709e-7,0.000002489489,0.000007847779,0.00004563554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4029515,"threshold_uncertainty_score":0.2218895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400510158353192,"score_gpt":0.3126797934176543,"score_spread":0.2986746918341224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}