{"id":"W1883167815","doi":"10.4049/jimmunol.0901409","title":"Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Calgary","funders":"National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; Commonwealth Foundation","keywords":"clone (Java method); Epitope; Affinity maturation; Polyclonal antibodies; Ganglioside; Biology; Molecular biology; Antibody; Immunohistochemistry; In vitro; Monoclonal antibody; Epitope mapping; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002978545,0.0004272564,0.0002756665,0.0001448262,0.0001233138,0.0003675018,0.0002816909,0.000265018,0.0009668999],"category_scores_gemma":[0.0002141851,0.0002278831,0.0002228095,0.0001314929,0.0001377272,0.0001877045,0.0003342882,0.0006586952,0.0003981297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003212056,"about_ca_system_score_gemma":0.0001789599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008271817,"about_ca_topic_score_gemma":0.001021485,"domain_scores_codex":[0.9996616,0.00007157269,0.00002253849,0.00005797272,0.00009497353,0.00009138751],"domain_scores_gemma":[0.9998521,0.00003640649,0.00003287723,0.00001908269,0.00003516075,0.00002430966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002057736,0.00000921193,0.00004868192,0.000004921982,0.000001634748,0.000008604619,0.000005502489,0.00002829003,0.9995096,0.00001200647,0.00000609203,0.0003448728],"study_design_scores_gemma":[0.000007300706,0.0001440221,0.000903117,0.000001274992,0.000008249928,0.0001007248,0.00000629137,0.0007495026,0.9975531,0.000008531093,0.0005164875,0.000001454607],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99375,0.0003413933,0.005272753,0.00002818972,0.000006623359,0.0000255877,0.00002717144,0.00003125994,0.0005168564],"genre_scores_gemma":[0.9905387,0.0004866125,0.006952985,0.00006945125,0.000008387703,0.00002526226,0.0002200798,0.00004810981,0.001650307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009668999,"threshold_uncertainty_score":0.003234625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400510158353192,"score_gpt":0.3126797934176543,"score_spread":0.2986746918341224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}