{"id":"W1883555758","doi":"10.1039/b105089n","title":"Reusable solid-phase supports for oligonucleotides and antisense therapeuticsElectronic supplementary information (ESI) available: CGE data for octathymidine phosphodiester sequences on supports P1–5, P7, P9, and P11–13 PAGE data for phosphorothioate products, dimethoxytrityl analysis and UV measurements on supports P1–7, P9 and P15, step listing for ABI394 DNA synthesizer and CGE and HPLC data for phosporothioate syntheses on support P3. See http://www.rsc.org/suppdata/p1/b1/b105089n/","year":2001,"lang":"en","type":"article","venue":"Journal of the Chemical Society Perkin Transactions 1","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Phosphodiester bond; Oligonucleotide synthesis; Linker; Anhydrous; Oligonucleotide; Solid-phase synthesis; Chemistry; Combinatorial chemistry; Glycolic acid; Nucleoside; Cleavage (geology); Chromatography; Stereochemistry; DNA; Organic chemistry; Biochemistry; Biology; RNA; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00279705,0.0005655205,0.0008644548,0.0001212492,0.0007537759,0.000277616,0.0005437934,0.0002966078,0.000009329741],"category_scores_gemma":[0.000606583,0.0004262526,0.0002251181,0.0002199078,0.0004348047,0.0003191126,0.0002210486,0.0002884825,7.735512e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006908437,"about_ca_system_score_gemma":0.0001740276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004597596,"about_ca_topic_score_gemma":0.00009582007,"domain_scores_codex":[0.9966918,0.00007710222,0.001035031,0.001181816,0.0003558744,0.0006584396],"domain_scores_gemma":[0.9966522,0.0006819998,0.0008083853,0.0012781,0.0003591927,0.0002201556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00937828,0.001106034,0.003161074,0.001982477,0.006513889,0.000008091616,0.0005179937,0.00001630255,0.9234622,0.00002716745,0.02371398,0.03011255],"study_design_scores_gemma":[0.004291196,0.002479171,0.0002166119,0.0003667876,0.006094672,0.0002880924,0.0006243509,0.01199729,0.8811021,0.0001999181,0.09145162,0.0008881839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9457166,0.001661759,0.02487257,0.003914601,0.0001371359,0.003443685,0.02021352,0.00003547557,0.0000046728],"genre_scores_gemma":[0.9241221,0.01116796,0.05697808,0.0009196873,0.000215862,0.0001064285,0.00625965,0.00007934408,0.000150883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06773765,"threshold_uncertainty_score":0.9998189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05889253509072837,"score_gpt":0.3385886577308667,"score_spread":0.2796961226401383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}