{"id":"W1885268003","doi":"10.1038/ncomms8286","title":"A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Breast Cancer Campaign; National Institute for Health and Care Research; Cancer Research UK","keywords":"Filopodia; CDC42; Cell biology; Guanine nucleotide exchange factor; Rac GTP-Binding Proteins; Angiogenesis; Cytokinesis; RAC1; Morphogenesis; Biology; Cell migration; Chemistry; GTPase; Cell; Signal transduction; Cell division; Actin; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114998,0.0004007373,0.0001276333,0.0003309532,0.000276975,0.0003682726,0.0001522948,0.0001946193,0.001194423],"category_scores_gemma":[0.0001067712,0.0001830753,0.0001766227,0.0000943652,0.0002150392,0.0001719248,0.0002850528,0.0003097072,0.0003459504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005614397,"about_ca_system_score_gemma":0.0002854676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009043649,"about_ca_topic_score_gemma":0.001970456,"domain_scores_codex":[0.9998901,0.00001353841,0.000005824699,0.00002425935,0.00003525523,0.00003096389],"domain_scores_gemma":[0.9999232,0.000006708388,0.00001885385,0.000008258212,0.000006590203,0.00003635069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005396828,0.000008933972,0.0001034287,0.00001310541,0.000002542069,0.00003744314,0.000005333854,0.00005428822,0.9990773,0.0001818724,0.00002886805,0.0004328917],"study_design_scores_gemma":[0.00001022925,0.00004724915,0.004760343,0.000002790654,0.000005743917,0.0001698683,0.00001299811,0.001085583,0.9912868,0.00005575386,0.00255902,0.0000035602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925563,0.001190698,0.003335853,0.00007464948,0.00002005639,0.00001901579,0.0002761055,0.00012281,0.002404461],"genre_scores_gemma":[0.9955226,0.0004321166,0.001487254,0.00001211068,0.000005542965,0.00001446631,0.0003719298,0.00001580339,0.00213816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001194423,"threshold_uncertainty_score":0.00407362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0476097085998543,"score_gpt":0.2935665821807015,"score_spread":0.2459568735808472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}