{"id":"W1885271015","doi":"10.1046/j.1365-2958.2003.03377.x","title":"A conserved region within the <i>Bordetella pertussis</i> autotransporter BrkA is necessary for folding of its passenger domain","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Biology; Secretion; Chaperone (clinical); Bacterial outer membrane; Mutant; Escherichia coli; Signal peptide; Effector; Bordetella pertussis; Protein folding; Transport protein; Cytoplasm; Cell biology; Biochemistry; Peptide sequence; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001319434,0.0004283342,0.0004100292,0.0001603422,0.0003264479,0.0003904096,0.0002959732,0.0005033394,0.0009323535],"category_scores_gemma":[0.0002448572,0.0003008767,0.0006575941,0.0002204352,0.0003389961,0.0003515301,0.0003226988,0.0006405657,0.0009258179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004210291,"about_ca_system_score_gemma":0.0004386918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153189,"about_ca_topic_score_gemma":0.001087212,"domain_scores_codex":[0.9998185,0.00003474995,0.00002815141,0.00003159207,0.00005030951,0.00003680919],"domain_scores_gemma":[0.9996686,0.00006229605,0.000118441,0.00003879776,0.0000237256,0.00008819099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001666212,0.00003112854,0.0003234007,0.00003795183,0.00000685348,0.0002393614,0.00002340333,0.00009505406,0.9984598,0.00008792035,0.00001905243,0.0005092974],"study_design_scores_gemma":[0.00004521186,0.0002793766,0.01647352,0.00002106191,0.00004622413,0.00187025,0.00008574894,0.0009725876,0.9780015,0.0001114054,0.002072074,0.00002102723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955454,0.0003157771,0.00298223,0.00009109658,0.00002410847,0.00001992165,0.0003245976,0.00007634646,0.0006204408],"genre_scores_gemma":[0.9959224,0.0001656629,0.002375948,0.00005861602,0.00001013229,0.00001180282,0.0009261612,0.00003466383,0.0004945894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153189,"threshold_uncertainty_score":0.003119051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009309615391233695,"score_gpt":0.2163103656706797,"score_spread":0.207000750279446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}