{"id":"W1885271015","doi":"10.1046/j.1365-2958.2003.03377.x","title":"A conserved region within the <i>Bordetella pertussis</i> autotransporter BrkA is necessary for folding of its passenger domain","year":2003,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Biology; Secretion; Chaperone (clinical); Bacterial outer membrane; Mutant; Escherichia coli; Signal peptide; Effector; Bordetella pertussis; Protein folding; Transport protein; Cytoplasm; Cell biology; Biochemistry; Peptide sequence; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003060658,0.0002701914,0.0003206564,0.00005547134,0.000104026,0.00001424772,0.0003568801,0.0006297989,0.00002006942],"category_scores_gemma":[0.00006547078,0.0002045644,0.0002465645,0.0001245958,0.0002872823,0.000002177244,0.00007129912,0.0001420001,0.000003012048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009567482,"about_ca_system_score_gemma":0.0001059848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005701601,"about_ca_topic_score_gemma":0.00001836538,"domain_scores_codex":[0.9983982,0.0001958831,0.0004331642,0.0005394951,0.0000415955,0.0003916688],"domain_scores_gemma":[0.9989779,0.00002569517,0.0002373108,0.0005622733,0.0001474912,0.00004930971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273154,0.00005298412,0.0001756495,0.00004050584,0.0001495495,0.000007940922,0.00006258738,0.0000081182,0.9962151,0.001502126,0.001483816,0.0001742773],"study_design_scores_gemma":[0.000771612,0.0003681698,0.00003809878,0.00001527063,0.0000493581,0.0001489489,0.00006085687,0.0000066474,0.8421384,0.0003006129,0.1558775,0.0002245566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879634,0.003042295,0.005860146,0.00187757,0.0003483607,0.000604881,0.00009424344,0.00001629912,0.0001928555],"genre_scores_gemma":[0.9944098,0.0002286817,0.00241964,0.002454385,0.00004934697,0.00005523868,0.0001416143,0.00004379858,0.0001974777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1543936,"threshold_uncertainty_score":0.8341893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009309615391233695,"score_gpt":0.2163103656706797,"score_spread":0.207000750279446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}